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  • Can the nano be flashed with either bootloaders or are there hardware differences that the booloader depends on? Commented Apr 18, 2018 at 14:44
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    There are no hardware differences. If you're flashing the bootloader my advice is to do so with Tools > Board > Arduino/Genuino Uno selected because then you get all the benefits of optiboot, including the 1.5 kB extra flash memory. Just remember that you need to have the Uno board when you use your Nano after that. Commented Apr 18, 2018 at 21:01
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    *Uno board selected Commented Apr 19, 2018 at 0:12
  • It might be worth noting: I have just received a Nano "clone" of AliExpress, which (unusually for a clone) has a FT232R (instead of a CH34x), which means that it works nicely on my Mac. However, I found that I had to select the old bootloader to be able to upload sketches - which seems contra your post (stating that the new bootloader is used for the Nano). However, as my Nano is a clone, I guess that anything goes. Commented Apr 16, 2023 at 22:50