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The PPAR�leukotriene B4 pathway to inflammation control

Nature volume 384, pages 39–43 (1996) Cite this article

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Abstract

Inflammation is a local immune response to 'foreign' molecules, infection and injury. Leukotriene B4, a potent chemotactic agent that initiates, coordinates, sustains and amplifies the inflammatory response, is shown to be an activating ligand for the transcription factor PPARα. Because PPARα regulates the oxidative degradation of fatty acids and their derivatives, like this lipid mediator, a feedback mechanism is proposed that controls the duration of an inflammatory response and the clearance of leukotriene B4 in the liver. Thus PPARα offers a new route to the development of anti- or pro-inflammatory reagents.

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Author notes

  1. Hansjörg Keller

    Present address: Core Drug Discovery Technologies, K-681.4.42 CIBA-Geigy, CH-4002, Basel, Switzerland

  2. Manuel Vazquez

    Present address: Unidad de Farmacologia y Farmacognosia, Facultad de Farmacia, Barcelona, E-08028, Spain

Authors and Affiliations

  1. Institut de Biologie animale, Université de Lausanne, CH-1015, Lausanne, Switzerland

    Pallavi R. Devchand, Hansjörg Keller, Manuel Vazquez & Walter Wahli

  2. Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Jeffrey M. Peters & Frank J. Gonzalez

Authors
  1. Pallavi R. Devchand
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  2. Hansjörg Keller
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  3. Jeffrey M. Peters
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  4. Manuel Vazquez
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  5. Frank J. Gonzalez
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  6. Walter Wahli
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Devchand, P., Keller, H., Peters, J. et al. The PPARα–leukotriene B4 pathway to inflammation control. Nature 384, 39–43 (1996). https://doi.org/10.1038/384039a0

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