Issues

• Help in understanding - most generated candidates are not close to the hotspots defined

  RosettaCommons/RFantibody#102 · Filter by author topcat opened on Aug 21, 2026
  1

• hotspot_show_proportion=1 does not show all hotspots (random_round adds a coin flip)

  RosettaCommons/RFantibody#101 · Filter by author thisishyunkoo opened on Aug 10, 2026
  1

• Which original RFdiffusion checkpoint was used to initialize RFantibody training?

  RosettaCommons/RFantibody#100 · Filter by author huoyidan111 opened on Jul 25, 2026

• PermissionError: [Errno 13] Permission denied: 'outputs'

  RosettaCommons/RFantibody#99 · Filter by author DStrelak opened on May 22, 2026

• running nanobody example

  RosettaCommons/RFantibody#98 · Filter by author grandrea opened on May 21, 2026

• RF2 part

  RosettaCommons/RFantibody#97 · Filter by author truzmeto opened on May 8, 2026

• unknown // undocumented harcoded files path

  RosettaCommons/RFantibody#95 · Filter by author EricDeveaud opened on Apr 20, 2026

• Binding validation, p_bind

  RosettaCommons/RFantibody#91 · Filter by author truzmeto opened on Apr 13, 2026
  2

• When I was designing, I specified L1:14, L3:11, H2:6, H3:15, but in the generated results, the lengths of L1, L3, H2, and H3 are not fixed. In some cases, H3 even reaches a length of 22 residues.

  RosettaCommons/RFantibody#90 · Filter by author xiaoxuc opened on Apr 7, 2026

• cannot find the primary config "nanobody"

  RosettaCommons/RFantibody#88 · Filter by author ulloaa opened on Mar 2, 2026

• DGL not compatible with newer Pytorch - build from source or port out to Pytorch Geometrics (pyg)?

  RosettaCommons/RFantibody#86 · Filter by author topcat opened on Feb 19, 2026
  5

• RF2 interaction PAE regression after THL chain reordering refactor

  RosettaCommons/RFantibody#85 · Filter by author evalkov opened on Feb 18, 2026
  1

• Running 5o45 target leads to rotation matrix all-zero error, while other targets work

  RosettaCommons/RFantibody#84 · Filter by author jiejie-920 opened on Feb 7, 2026
  2

• keep fixed one residue and change the others

  RosettaCommons/RFantibody#83 · Filter by author aspitaleri opened on Feb 1, 2026

• Google Colab notebook for RFantibody (no Docker required)

  RosettaCommons/RFantibody#79 · Filter by author Fahad8389 opened on Jan 26, 2026
  6

• Fail to reproduce the results reported in the paper

  RosettaCommons/RFantibody#78 · Filter by author lampreyyang opened on Jan 6, 2026
  3

• ModuleNotFoundError: No module named 'rfantibody.proteinmpnn.quiver'

  RosettaCommons/RFantibody#77 · Filter by author wangxiao2037 opened on Jan 3, 2026

• chain scission on antigen

  RosettaCommons/RFantibody#76 · Filter by author yangly-simon opened on Dec 19, 2025
  1

• Low success rate in wet lab experiments.

  RosettaCommons/RFantibody#75 · Filter by author Hai-W-L opened on Dec 5, 2025
  2

• Designing full-length IgG1 antibodies with strong Fc-mediated opsonization using RFantibody

  RosettaCommons/RFantibody#74 · Filter by author 8MaCaVeL8 opened on Dec 4, 2025

• Does RFantibody only run on one GPU?

  RosettaCommons/RFantibody#73 · Filter by author xiaodiyu opened on Dec 3, 2025

• Is it possible to design only specific residue(s) on a CDR?

  RosettaCommons/RFantibody#72 · Filter by author fivecanal5 opened on Dec 1, 2025
  2

• Design Relies on Existing Loops in Fwr PDB

  RosettaCommons/RFantibody#71 · Filter by author simonlevine opened on Nov 26, 2025

• TCR design

  RosettaCommons/RFantibody#69 · Filter by author kdnghw opened on Nov 20, 2025

• Is partial diffusion not supported?

  RosettaCommons/RFantibody#68 · Filter by author fivecanal5 opened on Nov 19, 2025