You answered your question yourself:
To a large extent, US pressure seems to have in response to Japanese aggression in China. An aggression which involved atrocities such as the Rape of Nanjing.
This was an atrocity beyond anything people had experienced, apart from trench warfare. That fact alone was more than enough reason. Most western nation sanctioned Japan, not just the USA.
Another less altruistic reason is the expansion of Japanese influence in China. That wasn't exactly in the interest of America. Compare it with 'Let Germany (prior WO 1 & 2) rule Central Europe. It doesn't affect England'Great Britain'.
Japan controlling most of China would be the same for the USA as Germany controlling continental Europe for Englandthe Kingdom of Great Britain and Northern Ireland.