Here the authors examine dopamine dynamics as a regulatory mechanism for shifting between defensive and reward-seeking behaviors.

Wide-field imaging in mice resolves state-dependent cortical blood-volume dynamics and reveals a REM-sleep paradox, where blood volume and astrocytic pyruvate rise while neuronal ATP falls, uncovering a dissociation between supply and consumption.

Cancer spheroid-fibroblast “flower-like” interactions revealed and tracked in 3D using high-throughput imaging and PSF engineering.

The prevalence of Clonal Haematopoiesis (CH) driven by mosaic chromosomal alterations is lower in people with HIV in comparison with people without HIV, which contrasts with the higher prevalence of CH driven by SGMs in people with HIV.

Bumblebee workers learn novel odors associated with their queen during colony development. These learned social cues influence attraction and context-dependent reproduction, demonstrating that responses to queen signals are shaped by experience.

The legume Medicago truncatula transmits stress signals to neighbours through mycorrhizal network, reshaping leaf defence and metabolism and causing pathogen-specific effects, from greater Fusarium resistance to Botrytis susceptibility.

ArgR directly represses nrf transcription to couple nitrogen metabolism with aerobic oxidative stress defense in pathogenic Aeromonas veronii, revealing a conserved regulatory axis within Gammaproteobacteria.

Quantifying how diet and infection reshape the Drosophila midgut reveals distinct cellular strategies underlying epithelial remodeling and organ size control.

Single-nucleus transcriptomics of large-cell pancreatic neuroendocrine carcinoma uncovers aberrant brain-type neuronal programs and stress-responsive cell states, revealing therapeutic vulnerabilities for this aggressive cancer

Hepatocyte nuclear factor-1α (HNF1A) is identified as both a direct transcriptional target of BRD4 and a critical determinant of the anti-neoplastic activity of BET-inhibitors in pancreatic ductal adenocarcinoma.

As neuron models grow more detailed, the uncertainty behind them often collapses into single best-fit parameters, obscuring what the data support. This Comment argues for reference-grade modeling standards, with traceable provenance, declared uncertainty, and ensemble predictions, adapted from the hierarchy of standards used in analytical chemistry.

Not many pathogens are as uniquely adapted as Streptococcus pyogenes to cause a variety of infections ranging from strep throat to serious flesh-eating skin infections. Yet, scientists, to date, have had limited knowledge into the extent of diseases strep caused in the past. In a new study, Valverde et al. found the signature of strep in the tooth of a mummified individual from a sea of sequencing data and traced the past of the pathogen.

In this comment, the author discusses the next two frontiers of artificial intelligence in structural biology: the prediction of full protein conformational landscapes and the routine de novo design of high-affinity protein binders.

Current preclinical models fail to capture the mechanics of oligodendrocyte myelination. Lasli et al.¹ now demonstrate that the mechanical compliance of the axonal niche is a key determinant of oligodendrocyte maturation. By developing a platform that mimics the extreme mechanical softness of the central nervous system, they reveal myelination as a mechanically gated process as much as a biochemically regulated one.

Global regulatory shifts are accelerating the move from animal models to human-relevant systems like organoids and MPS. Without deliberate inclusion, Africa risks exclusion despite its high disease burden, limiting global health equity and full scientific potential.

Dr. Victor Borda is a Research Associate at the University of Maryland, School of Medicine, and the Institute for Health Computing. In this Q&A, we discuss his recent publication in Communications Biology on admixture and genetic diversity across Peru, his work with the Peruvian Genome Project, and the relevance of developing genomic resources in Latin America.