Latest research
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Characterizing single-shell NODDI-DTI estimates through associations with plasma biomarkers and cognitive performance
White matter (WM) degeneration is an important feature of aging and Alzheimer’s disease (AD). Neurite orientation dispersion and density imaging derived from diffusion tensor imaging (NODDI-DTI) is a technique that allows the estimation of neurite...
Criteria-based probable REM sleep behaviour disorder and risk of Lewy body dementia: analyses of a memory clinic cohort and a community cohort
Background REM sleep behaviour disorder (RBD) is the strongest prodromal marker of alpha-synucleinopathies, but whether a brief questionnaire carries prognostic information for Lewy body dementia is unclear. We tested whether criteria-based probable...
Skin carotenoid levels are associated with blood amyloid-beta 42/40 ratios in healthy individuals under 60 years of age
Dementia prevalence is increasing worldwide, with Alzheimer’s disease (AD) being the most common type. Amyloid-beta (Aβ) aggregation is an early pathological event in AD. Although carotenoids have been shown in vitro to inhibit Aβ aggregation...
Multimodal PET–MRI profiling predicts dementia with Lewy bodies in isolated REM sleep behaviour disorder
Despite isolated REM sleep behaviour disorder (iRBD) reliably identifying individuals at high risk of developing Parkinson’s disease (PD) or dementia with Lewy bodies (DLB), with more than 90% converting, the neurobiological markers of the...
Indoor air pollution and cognitive health in older adults: a systematic review and meta-analysis
Background Maintaining cognitive health in older adults is an important public health challenge. We systematically evaluated associations between indoor air pollution (IAP) exposure and global cognitive function, cognitive subdomains, and cognitive...
Oxidative stress-induced microglial CD22 upregulation impairs phagocytosis and exacerbates Huntington’s disease
Background Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal polyglutamine expansion in mutant huntingtin (mHTT) and is characterized by movement dysfunction and neuronal loss. Siglecs, a family of sialic acid-binding...
Interplay of TREM2 and APOE in Alzheimer’s disease: mechanisms, imaging biomarkers, and therapeutic opportunities
Alzheimer’s disease (AD) is the most common neurodegenerative disorder. AD features dysregulated innate immune elements and lipid metabolism which could contribute to its neuropathology. In this line, microglial triggering receptor expressed on...
Different functional connectivity gradients reflect aging and Alzheimer’s disease
Aging and Alzheimer’s disease (AD) are accompanied by alterations to large-scale communication patterns in the brain, which can be tracked in vivo using functional connectivity. The location, direction and relevance of these changes remain widely...
Multiscale characterization and distribution of the thyroid hormone transporter MCT8 in the adult and aged human brain
The local availability of thyroid hormones (TH) depends on TH transporters such as monocarboxylate transporter 8 (MCT8, encoded by SLC16A2). Mutations of SLC16A2cause Allan-Herndon-Dudley syndrome (AHDS), a disorder characterized by severe...
Higher HDL cholesterol is associated with greater amyloid-β oligomerization in older adults
Background Higher high-density lipoprotein cholesterol (HDL-C) is conventionally expected to be protective, yet evidence in Alzheimer’s disease (AD) is inconsistent and may be non-linear; its relationship to amyloid-β (Aβ) oligomerization—an early,...
Association between musculoskeletal pain and risks of dementia in middle-aged and older Chinese adults: the mediating role of depressive symptoms
Background Musculoskeletal pain (MSP) and dementia are prevalent in aging populations, yet the relationship linking them remains inadequately understood. This research explored whether depressive symptoms mediated the association between MSP and...
Serum insulin-like growth factor-1 and its association with epilepsy risk and cognitive function
Background Insulin-like growth factor 1 (IGF-1) has neurotrophic and neuroprotective properties, but its relationship with epilepsy risk and cognitive outcomes remains unclear. We investigated whether serum IGF-1 was associated with incident epilepsy...
Commercially available apps for the treatment of people living with dementia and mild cognitive impairment: a systematic review. What evidence and what urgencies from a public health perspective?
Background Digital cognitive-oriented therapies (COTs) delivered through commercially available apps are increasingly used for individuals with mild cognitive impairment (MCI) or dementia, yet evidence regarding their effectiveness and classification...
tRNA-Derived Small RNAs in Alzheimer’s Disease: Interpreting Fragmented Observations Through a Stress–Translation Framework
Alzheimer’s disease (AD) is traditionally explained by amyloid-β (Aβ) and tau pathology, but this protein-centric view does not fully account for early and persistent metabolic, proteostatic, and stress-related disturbances. Emerging evidence points...
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