Uncover the latest and most impactful research in IgA nephropathy. Explore pioneering discoveries, insightful ideas and new methods from leading researchers in the field.
Sera from 26 patients from New York State with culture and PCR confirmed human granulocytic anaplasmosis (HGA) were used to assess the performance of three different immunofluorescence assays (IFA), combined IgG/IgA/IgM and separate IgM and IgG to...
Background Adverse event reports of glomerular diseases (GDs) following coronavirus disease 2019 (COVID-19) vaccination collected nationally have been shared to VigiBase, the global database of adverse event reports for medicines and vaccines. From...
Background A D-dimer is frequently elevated during acute childhood immunoglobulin A vasculitis (IgAV), but this finding is often misinterpreted as direct evidence of thrombosis. This review examines its mechanistic basis, clinical associations,...
Background Concurrent performance of therapeutic plasma exchange (TPE) and continuous renal replacement therapy (CRRT) via a single vascular access in critically ill patients may reduce interruptions; nonetheless, this requires careful circuit design...
Amyloidosis is a group of diseases caused by the deposition of abnormal protein fibrils in the extracellular space. These amyloid deposits can affect almost any organ system, with the kidney being the most commonly involved organ. In the present...
Background Precise epidemiological statistics regarding IgA nephropathy (IgAN) are essential for healthcare resource allocation and optimal therapeutic management. However, a nationwide epidemiological study has not been conducted in Japan over the...
IgA vasculitis (IgAV) is the most common systemic vasculitis in childhood. Its seasonal distribution and frequent respiratory or gastrointestinal prodromes implicate environmental exposures. However, microbiological detection temporally proximate to...
Background IgA vasculitis (IgAV) is the most common systemic vasculitis in children. The progression of IgA vasculitis nephritis (IgAVN) to chronic kidney disease can be as high as 20%. However, the molecular mechanism underlying IgAVN pathogenesis...
Background Persistent microhematuria is associated with disease progression in immunoglobulin A nephropathy (IgAN), but most of the studies that established the association were conducted outside of the United States (US). This real-world study...
Background Phase 3 interim reports have expanded the evidence for therapies targeting a proliferation-inducing ligand (APRIL) alone or both B-cell activating factor (BAFF) and APRIL in IgA nephropathy (IgAN). We evaluated their effects relative to...
Ifosfamide (IFO) is an effective chemotherapeutic agent, but its clinical use is limited by dose-dependent nephrotoxicity. This study investigated the protective effects of 18β-glycyrrhetinic acid (18β-GA) against IFO-induced acute renal injury and...
Background Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is an antibody mediated demyelinating disorder of the central nervous system with a spectrum of clinical presentations and severity, including a subgroup of patients requiring...
Background Although sodium–glucose cotransporter 2 inhibitors (SGLT2is) induce an initial estimated glomerular filtration rate (eGFR) dip, its positive prognostic significance demonstrated in previous reports has not been fully translated into...
During early pregnancy, the maternal immune system recalibrates to tolerate the semi-allogeneic fetus. Immunoglobulin (Ig) function is modulated by glycosylation. Prior studies showed increases in anti-inflammatory glycosylation traits...
Staphylococcus-associated glomerulonephritis (SAGN) is a subtype of infection-related glomerulonephritis (IRGN) that often affects older adults and can progress rapidly. The role of immunosuppressive therapy in IRGN remains controversial due to the...
Purpose Immunoglobulin A nephropathy (IgAN) is characterized by glomerular deposition of immunoglobulin A, with current treatments focused on controlling disease activity and slowing progression. In the context of expanding therapeutic options, this...
Background Risk of pyelonephritis is very high among patients with diabetes. During diabetes, the oral antidiabetic drug, dapagliflozin (DAPA) is commonly prescribed for its well-recognized renoprotective effects. Although DAPA lowers renal glucose...
