Latest research
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Migraine 1-2-3-4-5: a candidate communication aid for adult migraine without aura
Migraine remains under-recognised despite its substantial global burden. This Correspondence presents Migraine 1-2-3-4-5 as a candidate communication aid for adults aged 18 years or older with recurrent headache. It reorganises selected positive...
Illness Perception and its Association with Emotional Distress Among Adults with Migraine: A Cross-Sectional Study
Background Migraine is a prevalent and disabling neurological disorder that significantly impairs quality of life. In Pakistan, limited awareness, stigma, and sociocultural misconceptions often delay diagnosis and treatment. Understanding how...
Post Hoc Analysis of Time to First and Sustained Improvement in Weekly Migraine Days Among Patients Receiving Preventive Treatment With Rimegepant 75 mg
Introduction For preventive migraine treatment, understanding an intervention’s onset, extent of action, and duration can help set realistic treatment expectations and may help prevent both premature discontinuation and reduce unnecessary prolonged...
The Migraine Care Gap: A Qualitative Analysis of Patients’ Perspectives on Medical Progress and Persistent Unmet Needs
Introduction Despite remarkable advances in migraine diagnosis and treatment, it remains unclear to what extent these developments have translated into meaningful improvements in the everyday lives of people living with migraine. This qualitative...
Selumetinib may alleviate migraine in a patient with neurofibromatosis type 1 (NF1): a case report
Background Neurofibromatosis type 1 (NF1) is an autosomal dominant multisystem disorder resulting from loss-of-function mutations in the NF1gene. Deficiency of neurofibromin leads to hyperactivation of the Ras/MEK/ERK and PI3K/Akt/mTOR pathways,...
Mu-opioid receptor-positive neurons in rostral ventromedial medulla drive pain sensitization after traumatic brain injury in both male and female mice
Persistent headache and pain hypersensitivity are common after mild traumatic brain injury (mTBI). However, the central mechanisms that support posttraumatic pain sensitization are not fully understood. The rostral ventromedial medulla (RVM), a key...
Altered hierarchical brain structure–function coupling in episodic and chronic migraine
Background Migraine is increasingly recognized as a network disorder involving distributed structural and functional brain alterations. However, regional changes in the relationship between resting-state activity and white-matter organization remain...
Persistence and Reasons for Treatment Discontinuation of Anti-CGRP Therapies in Migraine Prophylaxis: A Systematic Review and Meta-analysis of Real-World Studies
Introduction Anti-calcitonin gene-related peptide (anti-CGRP) therapies have become a mainstay of migraine prophylaxis. In routine care, treatment persistence and the reasons patients discontinue are indicators of long-term effectiveness,...
In the heat of the moment: prevalence and clinical characteristics of headache associated with sexual activity (head HEATS study)
Background Headache associated with sexual activity (HAS) is an uncommon and understudied primary headache disorder. Previous epidemiological studies have estimated a lifetime prevalence of approximately 1.0–1.6%, although the true prevalence remains...
Headache attributed to a past spontaneous intracranial hypotension: a new diagnostic entity
Background Spontaneous intracranial hypotension (SIH) is attributed to spinal cerebrospinal fluid (CSF) leaks and typically presents with orthostatic headache. Although persistent headache has been reported in some patients after radiologic...
Weather factors associated with recorded headache events and user-level meteorological recording profiles in smartphone headache diary data: a retrospective observational study
Background Weather changes are commonly reported as headache triggers, but the relationship between specific meteorological conditions and headache occurrence remains inconsistent across studies. We investigated if weather variables and user-level...
Glymphatic–Hippocampal Axis Alterations Across the Migraine–Medication Exposure Continuum: A Multi-modal Neuroimaging Study
Introduction Medication-overuse headache (MOH) is a debilitating consequence of analgesic use, yet its pathophysiology remains incompletely characterised. Impaired glymphatic clearance may contribute to headache chronification. We investigated...
Distinct neuronal subpopulations in the anterior pretectal nucleus contribute to nitroglycerin-induced cephalic and extracephalic mechanical hypersensitivity
Background Chronic migraine is characterized by recurrent headache and persistent pain hypersensitivity, often accompanied by sensory symptoms such as photophobia. Although central sensitization within thalamic and brainstem circuits is thought to...
Clinical phenotype and diagnostic criteria of cardiac cephalalgia: a systematic review and individual patient data meta-analysis
Cardiac cephalalgia is an uncommon manifestation of myocardial ischemia whose clinical phenotype and concordance with current International Classification of Headache Disorders 3rd edition (ICHD-3) diagnostic criteria remain poorly defined. We aimed...
Cluster headache care gaps among primary healthcare physicians in the Middle East, North Africa, and Türkiye: a multinational study
Background Cluster headache is one of the most severely disabling primary headache disorders and is frequently associated with diagnostic delay, inappropriate treatment, disability, and substantial psychosocial burden. Because primary healthcare...
A Global Perspective on Migraine Attack Triggers: Understanding Differences Across Lifestyles, Religions, and Regions
Purpose of Review This review aims to summarize migraine attack triggers and understand variance across lifestyles, religions, and regions. Recent Findings Experts from 11 countries collaborated to suggest a definition of migraine attack triggers....
Migraine and related burden among employees of participating enterprises in China: a cross-sectional study
Objective Migraine imposes a substantial burden on working-age populations, but evidence on migraine burden of industry category among enterprise employees remains limited. This study aimed to describe the proportion of employees meeting migraine...
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