Latest research

  1. Article

    From voxels to models: a multi-center voxel-based morphometry study identifying robust biomarkers for deep learning classification of schizophrenia

    • Mohammed Jajere Adamu
    • Li Qiang
    • Charles Okanda Nyatega

    Background The application of deep learning in psychiatric disorders such as schizophrenia has lagged behind neuro-oncology, primarily due to a lack of identifiable neuroanatomical targets and concerns regarding generalizability across sites....

    01 October 2026
  2. Article

    Relieving the Burden on Caregivers: A Single-Group, 4-Week Pilot Study Evaluating the Impact of a Brief Online Psychoeducation Program (AES) on Burden Reduction and Schizophrenia-Related Knowledge for Informal Caregivers of Individuals with Schizophrenia in German-Speaking Countries

    • Yannik Fabian Dicker
    • Steffen Moritz
    • Anna Theil

    Purpose Informal caregivers of people with schizophrenia often face substantial psychological burden and limited support. Although psychoeducational family interventions are effective and are recommended by international guidelines, their clinical...

    29 September 2026 Open access
  3. Article

    The proposed barrier dysfunction axis in psychiatric disorders: a systematic review and meta-analysis of circulating zonulin and claudin-5

    • Oguzhan Kılınçel
    • Furkan Bulut
    • Şenay Kılınçel

    Background Emerging evidence suggests that disruption of the gut–brain axis, particularly involving intestinal permeability and blood–brain barrier (BBB) integrity, may play a critical role in the pathophysiology of psychiatric disorders. However,...

    29 September 2026 Open access
  4. Article

    Increased gamma oscillations and inter-regional brain asymmetry associated with sepsis-associated delirium: a prospective cohort study

    • Jie Liu
    • Anqi He
    • Keliang Xie

    Background Sepsis-associated delirium (SAD) is thought to involve disrupted functional brain network connectivity. The aim of this study was to characterize the electroencephalographic (EEG) features of SAD and to develop a predictive model based on...

    26 September 2026 Open access
  5. Article

    The role of social support in transdiagnostic symptom networks in affective and psychotic disorders: a cross-sectional and longitudinal network analysis

    • Rui Tan
    • Frederike Stein
    • Tilo Kircher

    Symptoms and psychosocial factors interact dynamically across affective and psychotic disorders, yet longitudinal evidence remains limited. Building on the network theory of psychopathology, this study conceptualizes mental disorders as systems...

    26 September 2026 Open access
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