Uncover the latest and most impactful research in Stress Signalling. Explore pioneering discoveries, insightful ideas and new methods from leading researchers in the field.
Background Vitamin D signalling, primarily through the vitamin D receptor (VDR), regulates cellular survival and programmed cell death. This systematic review aims to synthesise current evidence on the role of vitamin D in pancreatic β-cell apoptosis....
Myocardial ischemia/reperfusion (I/R) injury has been extensively studied, yet the underlying neuroinflammatory mechanisms are not fully understood. While toll-like receptor 4 (TLR4) is known to be involved in neuropathic pain and neurodegeneration,...
Synaptic dysfunction and intracellular accumulation of pathological tau are convergent hallmarks of Alzheimer’s disease (AD) and related tauopathies, yet the molecular mechanisms coupling these events to widespread neurodegeneration remain...
Aconitine-induced cardiotoxicity is a serious adverse effect of Aconitum-containing medicines, with myocardial injury and malignant ventricular arrhythmias representing important clinical manifestations. However, the molecular responses underlying...
Background Uncontrolled macrophage activation drives excessive inflammation in sepsis-associated acute respiratory distress syndrome (ARDS). Xuebijing (XBJ) injection has been widely used as an adjunctive therapy for sepsis, but the molecular...
Salinity poses a significant abiotic challenge for lentil, especially in dry and sub-arid regions. Salt stress hampers germination, seedling establishment and vegetative growth by impeding water absorption and causing ionic toxicity, nutrient...
In temperate forests, seedlings of Pinus koraiensisface multiple stressors such as drought, waterlogging and excessive fertilization, yet the physiological pathways leading to mortality remain poorly understood. Here, we subjected 7-year-old...
Lysosomal adaptation to environmental changes is critical for cellular and metabolic homeostasis and requires coordination by the mTORC1 kinase, which conveys nutritional and stress signals into distinct, substrate-specific outputs 1,2 . The FLCN–FNIP...
Group 1 metabotropic glutamate receptors (Gp1 mGluRs) are critical effectors in behavior. Abnormal Gp1 mGluR signaling is frequently observed in neurodevelopmental and cognitive disorders. It is established that activation of Gp1 mGluR elicits...
Testicular torsion is a common urological emergency; however, currently, there are no approved drugs to alleviate testicular ischemia/reperfusion (TI/R) injury. We investigated the protective effects and mechanisms of action of sophocarpine (SPC) as...
Torsion-induced ischemia causes lipid peroxidation in tissue, increases membrane permeability, and induces irreversible necroptosis in cells. The aim was to investigate the effects of thymoquinone (THQ) on receptor-interacting serine-threonine...
The present study investigates the impact of lipopolysaccharide (LPS) preconditioning on signaling transduction and downstream gene expression of the murine transcription factor STAT1 (Signal Transducer and Activator of Transcription 1). Wild‑type...
Background Obstructive sleep apnea (OSA) is a prevalent sleep disorder closely linked to endothelial dysfunction. This study aimed to evaluate the utility of three distinct endothelial cell activation and stress index (EASIX) variants in patients...
Key message Identifies ETFQO as a central target, showing H2S induces its alternative splicing to generate functionally distinct isoforms that are differentially persulfidated, coordinating stomatal and respiratory responses for drought adaptation. ...
Despite the established prognostic value of baseline tumor burden across multiple malignancies, the biological mechanisms linking tumor burden to responsiveness to anti-angiogenic therapy remain poorly understood. Here, we found that high tumor...
The kinase proteins are a superfamily in plants and are involved in diverse biological and molecular functions for better adaptation of land plants. Protein kinase diversification is hypothesized to enhance plant adaptation to abiotic stress,...
Sepsis-associated encephalopathy (SAE) usually causes long-term cognitive impairment, which seriously compromises the quality of life of patients, but the precise molecular mechanisms have not been elucidated. Formyl peptide receptor 1 (FPR1), a G...
Serum amyloid A3 (SAA3) is typically associated with inflammation, but its role in brown adipose tissue (BAT) thermogenesis remains elusive. Here, we identify SAA3 as a cold-inducible, locally acting amplifier of BAT thermogenesis. Using lentiviral...
TNF can activate both prosurvival and prodeath signaling downstream of tumor necrosis factor receptor 1 (TNFR1). Survival signaling originates from TNFR1-containing membrane-bound complex I, while death signaling is driven by cytosolic complex II....
Strigolactones (SLs) are carotenoid-derived phytohormones that play key roles in plant stress responses. They were initially identified as signaling molecules involved in parasitic seed germination and rhizosphere interactions. However, they are now...
Journal
Oncogene aims to make substantial advances in our knowledge of processes that contribute to cancer by publishing outstanding research. Oncogene...
