A few of the more obvious ones:
* Resolution of singularities in characteristic p
*Hodge conjecture
* Standard conjectures on algebraic cycles (though these are not so urgent since Deligne proved the Weil conjectures).
*Proving finite generation of the canonical ring for general type used to be open though I think it was recently solved; I'm not sure about the details.
For vector bundles, a longstanding open problem is the classification of vector bundles over projective spaces.