Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2009 Jul 4:10:47.
doi: 10.1186/1745-6215-10-47.

The impact of avoiding cardiopulmonary by-pass during coronary artery bypass surgery in elderly patients: the Danish On-pump Off-pump Randomisation Study (DOORS)

Kim Houlind  1 , Bo Juul Kjeldsen, Susanne Nørgaard Madsen, Bodil Steen Rasmussen, Susanne Juel Holme, Thomas Andersen Schmidt, Poul Erik Haahr, Poul Erik Mortensen; DOORS study group
Collaborators, Affiliations
Randomized Controlled Trial

The impact of avoiding cardiopulmonary by-pass during coronary artery bypass surgery in elderly patients: the Danish On-pump Off-pump Randomisation Study (DOORS)

Kim Houlind et al. Trials. .

Abstract

Background: Coronary Artery Bypass Graft operation for ischemic heart disease provides improved quality of life and, in some patients, prolonged survival. Concern has, however, been raised about complications that may be related to the use of cardiopulmonary by-pass (CPB) and aortic cross-clamping. It has been hypothesized that when coronary artery by-pass grafting is performed without the use of CPB, the rate of serious complications is reduced.

Methods/design: The trial is designed as an open, randomized, controlled, clinical trial with blinded assessment of end-points. Patients at or above 70 years of age, referred for surgical myocardial revascularisation, are included and randomised to receive coronary artery by-pass grafting either with or without the use of CPB and aortic cross-clamping. Follow-up is performed by clinical, biochemical, electrocardiographic, and angiographic data that are evaluated by independent committees that are blinded with respect to the result of the randomisation. End points include mortality, stroke, myocardial infarction, graft patency, quality of life, and cost-effectiveness. The trial is performed in four different Danish, cardiac surgery centres.

Trial registration: ClinicalTrials.gov NCT00123981.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cleveland JC, Shroyer LW, Chen AY, Peterson E, Grover FL. Off-pump Coronary Artery Bypass Grafting Decreases Risk-Adjusted Mortality and Morbidity. Ann Thorac Surg. 2001;72:1282–9. doi: 10.1016/S0003-4975(01)03006-5. - DOI - PubMed
    1. DeMaria RG, Carrier M, Fortier S, Martineau R, Fortier A, Cartier R, et al. Reduced mortality and strokes with off-pump coronary artery bypass grafting surgery in octogenarians. Circulation. 2002;106:I5–I10. - PubMed
    1. Al-Ruzzeh S, George S, Yacoub M, Amrani M. The clinical outcome of off-pump coronary artery bypass surgery in the elderly patients. European Journal of Cardio-thoracic Surgery. 2001;20:1152–56. doi: 10.1016/S1010-7940(01)00978-2. - DOI - PubMed
    1. Hirose H, Amano A, Takahashi A. Off-pump coronary artery bypass grafting for elderly patients. Ann Thorac Surg. 2001;72:2013–9. doi: 10.1016/S0003-4975(01)03147-2. - DOI - PubMed
    1. Nathoe HM, van Dijk D, Jansen EW, Suyker WJ, Diephuis JC, van Boven WJ, de la Riviere AB, Borst C, Kalkman CJ, Grobbee DE, Buskens E, de Jaegere PP, Octopus Study Group A comparison of on-pump and off-pump coronary bypass surgery in low-risk patients. N Engl J Med. 2003;348:394–402. doi: 10.1056/NEJMoa021775. - DOI - PubMed

Publication types

Associated data