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Review
. 2012 May 2;15(5):564-5.
doi: 10.1016/j.cmet.2012.04.009.

Omega 3 fatty acids and GPR120

Da Young Oh  1 , Jerrold M Olefsky
Affiliations
Review

Omega 3 fatty acids and GPR120

Da Young Oh et al. Cell Metab. .

Abstract

Human loss-of-function gene variants in GPR120 have recently been identified that confer increased risk for obesity and metabolic syndrome. In addition, GPR120 KO mice develop obesity, increased inflammation, and insulin resistance, consistent with a role for GPR120 signaling in the metabolic syndrome and diabetes mellitus.

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Figures

Figure 1
Figure 1. [LS1]GPR120 Is an ω3-FA Receptor/Sensor, and Loss of Function Leads to Obesity and Insulin Resistance
A small fraction (∼3%) of obese [LS2] carry a loss-of-function, nonsynonymous GPR120 variant (R270H) that exhibits impaired intrinsic signaling properties and inhibits ω3-FA stimulation of WT GPR120. In European populations, this variant is associated with increased risk for obesity and insulin resistance, and high-fat-fed GPR120 KO mice also develop obesity and insulin resistance.
See this image and copyright information in PMC

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