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. 2013:2013:581751.
doi: 10.1155/2013/581751. Epub 2013 Feb 21.

Targeting inflammation in emerging therapies for genetic retinal disease

Ishaq A Viringipurampeer  1 , Abu E Bashar, Cheryl Y Gregory-Evans, Orson L Moritz, Kevin Gregory-Evans
Affiliations

Targeting inflammation in emerging therapies for genetic retinal disease

Ishaq A Viringipurampeer et al. Int J Inflam. 2013.

Abstract

Genetic retinal diseases such as age-related macular degeneration and monogenic diseases such as retinitis pigmentosa account for some of the commonest causes of blindness in the developed world. Diverse genetic abnormalities and environmental causes have been implicated in triggering multiple pathological mechanisms such as oxidative stress, lipofuscin deposits, neovascularisation, and programmed cell death. In recent years, inflammation has also been highlighted although whether inflammatory mediators play a central role in pathogenesis or a more minor secondary role has yet to be established. Despite this, numerous interventional studies, particularly targeting the complement system, are underway with the promise of novel therapeutic strategies for these important blinding conditions.

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References

    1. Pascolini D, Mariotti SP. Global estimates of visual impairment 2010. British Journal of Ophthalmology. 2010;96(5):614–618. - PubMed
    1. Resnikoff S, Pascolini D, Etya’ale D, et al. Global data on visual impairment in the year 2002. Bulletin of the World Health Organization. 2004;82(11):844–851. - PMC - PubMed
    1. Wright AF, Chakarova CF, Abd El-Aziz MM, Bhattacharya SS. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Nature Reviews Genetics. 2010;11(4):273–284. - PubMed
    1. Tomany SC, Wang JJ, Van Leeuwen R, et al. Risk factors for incident age-related macular degeneration: pooled findings from 3 continents. Ophthalmology. 2004;111(7):1280–1287. - PubMed
    1. Tan JSL, Wang JJ, Flood V, Rochtchina E, Smith W, Mitchell P. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Ophthalmology. 2008;115(2):334–341. - PubMed

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