Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Nov;9(6):326-31.

Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals

Sedigheh Asgary  1 , Mahtab Keshvari  2 , Amirhossein Sahebkar  3 , Mohamad Hashemi  4 , Mahmoud Rafieian-Kopaei  5
Affiliations

Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals

Sedigheh Asgary et al. ARYA Atheroscler. 2013 Nov.

Abstract

Background: Pomegranate juice (PJ) is rich in bioactive phytochemicals with antioxidant, and anti-inflammatory and cardioprotective functions. The present trial investigated the acute effects of PJ consumption on blood pressure and markers of endothelial function.

Methods: In this single-arm study, thirteen hypertensive men aged 39-68 years were recruited. Included subjects were assigned to natural PJ (150 ml/day) following a 12 hour fast. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and flow-mediated dilation (FMD), along with serum concentrations of C-reactive protein (CRP), intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin and interleukin-6 (IL-6) were measured at baseline and 4-6 hours after PJ consumption.

Results: Comparison of pre- vs. post-trial values revealed a significant reduction in both SBP (7%; P = 0.013) and DBP (6%; P < 0.010). However, changes in FMD (20%) as well as circulating levels of CRP, ICAM-1, VCAM-1, E-selectin, and IL-6 did not reach statistical significance (P = 0.172).

Conclusion: PJ has promising acute hypotensive properties. Consumption of PJ could be considered in the context of both dietary and pharmacological interventions for hypertension.

Keywords: Cardiovascular Disease; Endothelium-Dependent Dilation; Hypertension; Inflammation; Punica Granatum L..

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Kochanek KD, Xu J, Murphy SL, Minino AM, Kung HC. Deaths: Final Data for 2009. National Vital Statistics Reports. 2011;60(3):1–110. - PubMed
    1. Whitworth JA. 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens. 2003;21(11):1983–92. - PubMed
    1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365(9455):217–23. - PubMed
    1. Hajjar I, Kotchen JM, Kotchen TA. Hypertension: trends in prevalence, incidence, and control. Annu Rev Public Health. 2006;27:465–90. - PubMed
    1. Fazizi F, Esmaillzadeh A, Mirmiran FP. Obesity and cardiovascular disease risk factors in Tehran adults: a population-based study. East Mediterr Health J. 2004;10(6):887–97. - PubMed

LinkOut - more resources