Peer review is a fundamental element of the modern scientific publishing process. It serves an important role in evaluating the quality of research and refining submitted manuscripts into accurate and impactful contributions to the existing scientific literature. Over the last two decades, opportunities for publication have skyrocketed, and the demand for peer reviewers has grown exponentially. Although the peer review process provides significant benefits, recruiting individuals as peer reviewers can be challenging. The most common obstacles include the time commitment needed to provide meaningful reviews and uncertainty about how to prepare a cohesive and beneficial peer review. This article offers prospective peer reviewers structured guidance to build confidence and enable them to perform effective reviews.