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Bruceine A protects nuclear receptor 4A1 from ubiquitin-degradation to alleviate mesangial proliferative glomerulonephritis.

Hu H, Li R, He K, Wu L, Li R, Lu J, Tian R, Zhang C, He J, Chen Y, Lai R, Zhang J, Wu J, Zheng Y, He J, Liu L, Chen X, Pan H. Hu H, et al. Signal Transduct Target Ther. 2025 Dec 5;10(1):397. doi: 10.1038/s41392-025-02495-2. Signal Transduct Target Ther. 2025. PMID: 41345104 Free PMC article.

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Pregnenolone promotes immune evasion through blocking endogenous retrovirus expression.

Huang C, Tao H, Zhou Y, Wu Q, Li M, Liu A, Zhu T, Yu C, Li P, Huang S, Guo H, Hu J, Wang G. Huang C, et al. Cell Metab. 2026 May 5;38(5):981-994.e8. doi: 10.1016/j.cmet.2025.12.020. Epub 2026 Jan 23. Cell Metab. 2026. PMID: 41579859

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L-lactic acid enhances type I interferon immune response and inhibits virus infection by promoting IRF9 L-lactylation.

Miao Y, Cui Q, Zhang T, Zhang R, Zhao Q, Zhou H, Zuo Y, Wang Q, Zhang Y, Zheng Z, He W, Liu C, Yuan Y, Zheng H. Miao Y, et al. Proc Natl Acad Sci U S A. 2026 Jan 6;123(1):e2521070123. doi: 10.1073/pnas.2521070123. Epub 2026 Jan 2. Proc Natl Acad Sci U S A. 2026. PMID: 41481472 Free PMC article.

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Inhibitors supercharge kinase turnover through native proteolytic circuits.

Scholes NS, Bertoni M, Comajuncosa-Creus A, Kladnik K, Guo X, Frommelt F, Hinterndorfer M, Razumkov H, Prokofeva P, Schwalm MP, Born F, Roehm S, Imrichova H, Santini BL, Barone E, Schätz C, Muñoz I Ordoño M, Lechner S, Rukavina A, Serrano I, Abele M, Koren A, Kubicek S, Knapp S, Gray NS, Superti-Furga G, Kuster B, Shi Y, Aloy P, Winter GE. Scholes NS, et al. Nature. 2026 Jan;649(8098):1032-1041. doi: 10.1038/s41586-025-09763-9. Epub 2025 Nov 26. Nature. 2026. PMID: 41299171 Free PMC article.

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Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of LKB1 and SYVN1.

Xu M, Lin X, Xu H, Hu H, Xue X, Zhang Q, Yu D, Tian S, Xie M, Li L, Tao X, Li X, Li S, Xie S, Tian Y, Liu X, Xu H, Wang Q, Zhang W, Liu S. Xu M, et al. J Clin Invest. 2026 Feb 2;136(3):e197592. doi: 10.1172/JCI197592. eCollection 2026 Feb 2. J Clin Invest. 2026. PMID: 41623165 Free PMC article.

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N¹-Methylpseudouridine directly modulates translation dynamics.

Rozman B, Broennimann K, Rajan KS, Nachshon A, Saha C, Arazi T, Mohan V, Geiger T, Wollner CJ, Richner JM, Westhof E, Yonath A, Bashan A, Stern-Ginossar N. Rozman B, et al. Nature. 2026 Mar;651(8105):533-541. doi: 10.1038/s41586-025-09945-5. Epub 2026 Jan 14. Nature. 2026. PMID: 41535458

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Artesunate Ameliorates APAP-induced Liver Injury by Promoting NEDD4L-Mediated Ubiquitination and Degradation of TXNIP.

Zhang Z, Zhang H, Guo H, Zhang X, Wang Y, Wang B, Wang T, Zhao G, Zhang Q, Gao F, Liang S, Jiang H, Ding Y, Du X, Zhang J, Zheng Y, Li X, Yuan B. Zhang Z, et al. Adv Sci (Weinh). 2026 May;13(27):e21818. doi: 10.1002/advs.202521818. Epub 2026 Feb 28. Adv Sci (Weinh). 2026. PMID: 41762705 Free PMC article.

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Curcumin augments mitophagy via Nrf2-PINK1-mediated, Parkin-dependent ubiquitination to suppress ferroptosis in post-cardiac arrest brain injury.

Li Z, Xu W, Ren S, Zheng Q, Xing J. Li Z, et al. Phytomedicine. 2026 May;154:158035. doi: 10.1016/j.phymed.2026.158035. Epub 2026 Mar 3. Phytomedicine. 2026. PMID: 41795472 Free article.

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Crotonate suppresses breast cancer metastasis and promotes immunotherapy response by inducing ACSS2-mediated EZH2-K348 crotonylation.

Liu B, Duan X, Wang G, Tang Y, Zhou K, Zhang J, Yu Y, Zhang H. Liu B, et al. Sci Adv. 2026 Jan 16;12(3):eaea9892. doi: 10.1126/sciadv.aea9892. Epub 2026 Jan 16. Sci Adv. 2026. PMID: 41544165 Free PMC article.

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HDAC5 deficiency induces intrinsic resistance to KRAS inhibition by disrupting c-Myc acetylation-ubiquitination homeostasis.

Chen T, Yu H, Wang K, Qin G, Zhao Y, Liang X, Li Y, Zou T, Liu J, Zhao J, Liu Z, Wei R, Wang B, Gou S, Yin T, Wu H, Jin X, Zhou Y. Chen T, et al. J Clin Invest. 2025 Dec 11;136(3):e195814. doi: 10.1172/JCI195814. eCollection 2026 Feb 2. J Clin Invest. 2025. PMID: 41379561 Free PMC article.

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