Bromazepam

Bromazepam
Klinički podaci
Prodajno ime	Apo-Bromazepam, Calmepam, Compedium, Compendium
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	10-20 h
Identifikatori
CAS broj	1812-30-2
ATC kod	N05BA08 (WHO)
PubChem	CID 2441
DrugBank	DB01558
ChemSpider	2347
ChEMBL	CHEMBL277062
Hemijski podaci
Formula	C14H10BrN3O
Molarna masa	316,153
	SMILES BrC1=CC2=C(NC(=O)CN=C2C2=CC=CC=N2)C=C1; ;
	InChI InChI=1S/C14H10BrN3O/c15-9-4-5-11-10(7-9)14(17-8-13(19)18-11)12-3-1-2-6-16-12/h1-7H,8H2,(H,18,19) ; Key:VMIYHDSEFNYJSL-UHFFFAOYSA-N ;

Bromazepam je benzodiazepin i organsko jedinjenje, koje sadrži 14 atoma ugljenika i ima molekulsku masu od 316,153 Da.^[1]^[2]^[3]^[4]^[5]^[6]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	1
Broj rotacionih veza	1
Particioni koeficijent^[7] (ALogP)	2,3
Rastvorljivost^[8] (logS, log(mol/L))	-4,6
Polarna površina^[9] (PSA, Å²)	54,4

Reference

^ Oelschläger, H. (1989). . „Chemical and pharmacologic aspects of benzodiazepines”. Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse de Medecine Praxis. 78 (27–28): 766—772. PMID 2570451.
^ Oda, M.; Kotegawa, T.; Tsutsumi, K.; Ohtani, Y.; Kuwatani, K.; Nakano, S. (Epub 2003 Sep 27). . „The effect of itraconazole on the pharmacokinetics and pharmacodynamics of bromazepam in healthy volunteers”. European Journal of Clinical Pharmacology. 59 (8–9): 615—619. PMID 14517708. S2CID 24131632. doi:10.1007/s00228-003-0681-4. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Van Harten, J. (1995). . „Overview of the pharmacokinetics of fluvoxamine”. Clinical Pharmacokinetics. 29 Suppl 1: 1—9. PMID 8846617. S2CID 71812133. doi:10.2165/00003088-199500291-00003.
^ Ochs, H. R.; Greenblatt, D. J.; Friedman, H.; Burstein, E. S.; Locniskar, A.; Harmatz, J. S.; Shader, R. I. (мај 1987). . „Bromazepam pharmacokinetics: Influence of age, gender, oral contraceptives, cimetidine, and propranolol”. Clinical Pharmacology and Therapeutics. 41 (5): 562—70. PMID 2882883. S2CID 1099919. doi:10.1038/clpt.1987.72.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). . „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Bromazepam

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Oelschläger, H. (1989). . „Chemical and pharmacologic aspects of benzodiazepines”. Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse de Medecine Praxis. 78 (27–28): 766—772. PMID 2570451.

[2] Oda, M.; Kotegawa, T.; Tsutsumi, K.; Ohtani, Y.; Kuwatani, K.; Nakano, S. (Epub 2003 Sep 27). . „The effect of itraconazole on the pharmacokinetics and pharmacodynamics of bromazepam in healthy volunteers”. European Journal of Clinical Pharmacology. 59 (8–9): 615—619. PMID 14517708. S2CID 24131632. doi:10.1007/s00228-003-0681-4. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[3] Van Harten, J. (1995). . „Overview of the pharmacokinetics of fluvoxamine”. Clinical Pharmacokinetics. 29 Suppl 1: 1—9. PMID 8846617. S2CID 71812133. doi:10.2165/00003088-199500291-00003.

[4] Ochs, H. R.; Greenblatt, D. J.; Friedman, H.; Burstein, E. S.; Locniskar, A.; Harmatz, J. S.; Shader, R. I. (мај 1987). . „Bromazepam pharmacokinetics: Influence of age, gender, oral contraceptives, cimetidine, and propranolol”. Clinical Pharmacology and Therapeutics. 41 (5): 562—70. PMID 2882883. S2CID 1099919. doi:10.1038/clpt.1987.72.

[5] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[6] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[7] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[8] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[9] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). . „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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