Yes, It is definitely possible. In our setup, typically we have django behind mod_wsgi, Apache and nginx
You can configure apache's Virtualhost, to point to a specific mod_wsgi which in turn points to specific code.
Quoting from here - Refer to the SO post for further information.
There are at least two methods you can try to serve from a single instance:
Use apache + mod_wsgi and use the WSGIApplicationGroup and/or WSGIProcessGroup directives. I've never needed these before so can't be completely sure these will work the way you want, but regardless you can definitely use mod_wsgi in daemon mode to greatly improve your memory footprint.
You can play with Django middleware to deny/allow URLs based on the request hostname (see HttpRequest.get_host() in the Django docs). For that matter, even though it would be a slight performance hit, you can put a decorator on all your views that checks the incoming host.
