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Tweet's answer can be passed to BrenBarn's answer above with

data.reindex_axis(sorted(data.columns, key=lambda x: float(x[1:])), axis=1)

So for your example, say:

vals = randint(low=16, high=80, size=25).reshape(5,5)
cols = ['Q1.3', 'Q6.1', 'Q1.2', 'Q9.1', 'Q10.2']
data = DataFrame(vals, columns = cols)

You get:

data

    Q1.3    Q6.1    Q1.2    Q9.1    Q10.2
0   73      29      63      51      72
1   61      29      32      68      57
2   36      49      76      18      37
3   63      61      51      30      31
4   36      66      71      24      77

Then do:

data.reindex_axis(sorted(data.columns, key=lambda x: float(x[1:])), axis=1)

resulting in:

data

    
     Q1.2    Q1.3    Q6.1    Q9.1    Q10.2
0    2       0       1       3       4
1    7       5       6       8       9
2    2       0       1       3       4
3    2       0       1       3       4
4    2       0       1       3       4