Laminar specific fMRI reveals directed interactions in distributed networks during language processing
Abstract
Laminar resolution, functional MRI (lfMRI) is a noninvasive technique with the potential to distinguish top-down and bottom-up signal contributions on the basis of laminar specific interactions between distal regions. Hitherto, lfMRI could not be demonstrated for either whole-brain distributed networks or for complex cognitive tasks. We show that lfMRI can reveal whole-brain directed networks during word reading. We identify distinct, language-critical regions based on their association with the top-down signal stream and establish lfMRI for the noninvasive assessment of directed connectivity during task performance.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- October 2019
- DOI:
- Bibcode:
- 2019PNAS..11621185S