As far as you need to be concerned as a .NET developer, you can freely interchange them as and when you feel like it.
Latest .NET Framework Classes Articles
Improved COM Interoperability in .NET 4.0
Learn about the COM Interoperability improvements coming with the .NET Framework 4.0 and how they will make your COM Interop such as Office applications much easier.
Creating Responsive .NET Applications with Microsoft Concurrency and Coordination Runtime (CCR)
Discover how CCR can work with the .NET Ping class APM functions.
An ADO.NET Data Services Tutorial
An ADO.NET Data Services Tutorial covering REST, querystring operations and expressions, HTTP verbs, Linq to Data Services, security, exceptions and tracing.
TIP: Closing your WCF Connections properly
This tip looks at properly closing a WCF connection from your application - whether you're using the proxy classes or a ChannelFactory.
New Features in Microsoft Visual Studio 2010 and the .NET Framework 4.0
Learn about several features relevant to developers in Visual Studio 2010 and the .NET Framework 4.0, such as parallel programming, XSLT debugging, new ASP.NET features, and new VB.NET and C# features that include the Chart control, XSD Designer, Lambda Expressions, and optional parameters.
Latest Developer Videos
More...Latest CodeGuru Developer Columns
C++ Tips and Tricks
Quirky and yet persistent, C++ is a language that keeps programmers coming back to it. Pick up some new ways to wrangle it into your workflow.

Working with Google Protocol Buffers and .NET
Learn about something called "Google Protocol Buffers," and watch for later posts on other IoT subjects.

Working with Primes and Fibonacci Sequences in Visual Basic
Play with the Fibonacci sequence and prime numbers in this example-driven article.

Lesson Learned: The Need for a Domain Language
Translation costs time and money, and can affect the quality of the product being made. Make sure all your team members speak the same language.