

Five-year-old Haleigh Cummings disappeared overnight from her home near Jacksonville, Florida, after her dad's girlfriend put her to bed.

Newlyweds Jessica and Matthew Boynton seemed like the picture-perfect couple, until the young mother was found unresponsive inside her locked bedroom closet.

A family camping trip to the remote Idaho mountains turned into something out of a horror movie when 2-year-old DeOrr Kunz disappeared.

Michelle Parker appeared on an episode of "The People's Court," fighting with her ex-fiancé over a diamond ring. Hours after the episode aired, Parker vanished.

College student Elisa Lam checked into a Los Angeles hotel, but never checked out. The last known images of her are from the hotel's elevator security camera.

Russell Dermond's body was found in the garage of his lakefront mansion. His wife was found dead, floating in the water. One key piece of evidence is missing.

Three young brothers vanished the day after Thanksgiving 2010. Their dad, who is now in prison, claimed he gave them to an underground group to protect them.

Lisa Irwin went missing from her crib in 2011 and has never been found. Stolen cell phones and a disturbing charge on a parent's debit card adds to the mystery.

Six-year-old Timmothy Pitzen vanished after a trip to waterparks and zoo with his mom. His mom was found dead in a motel room with a disturbing note.