Origin and history of malignancy

1560s, in reference to diseases, "virulent, tending to produce death," from French malignant and directly from Late Latin malignantem (nominative malignans) "acting from malice," present participle of malignare "injure maliciously," from Latin malignus "wicked, bad-natured," from male "badly" (see mal-) + -gnus "born," from gignere "to bear, beget" (from PIE root *gene- "give birth, beget").

Earlier in the church malignant "followers of the antichrist," from Latin ecclesiam malignantum in early Church writing, applied by Protestant writers to the Church in Rome (1540s). Of persons, "disposed to inflict suffering or cause distress," from 1590s. As an adjective, Middle English used simple malign (early 14c.), also malignous "poisonous, noxious." Related: Malignantly.

abstract noun suffix of quality or rank, ultimately representing in English Latin -cia, -tia (see -ia) but a living word-forming element in modern English. The native correspondents are -ship, -hood.