Act 432 granted authority and funding for Greenville General Hospital to deliver health care-related services countywide, setting the stage for the facility to expand and become a health organization with multiple campuses. This act broadened the hospital’s scope to become “an institution with an independent board of trustees, free from the control of either city or county authorities, which would be charged with the duty of operating the hospital and its expanded facilities for the benefit of the taxpayers and residents of all Greenville County.”

In 2016, the organization (then called Greenville Health System) determined it could better provide for the needs of the community and fulfill its statutory obligations by contracting with a newly formed, private not‑for‑profit entity. This entity, Prisma Health­–Upstate, leased the assets and assumed substantially all obligations of Greenville Health System, including the right to conduct business under that system’s name. Therefore, the name of the governmental entity that formerly owned Greenville Health System was officially changed in 2018 to Greenville Health Authority (GHA).