The top 50 pharmaceutical companies by prescription sales in 2025 – and their research and development (R&D) spending – included big names such as Johnson & Johnson, Novartis, and AbbVie. During that year, Eli Lilly's Rx sales were approximately billion U.S. dollars. Thus, the American pharma giant was both the largest pharmaceutical company based on pure pharma revenue worldwide.
Pharmaceutical R&D spending
Research and development in the pharmaceutical industry involves the identification and development of compounds used to make new drugs. The pharmaceutical industry has the largest percentage of spending attributable to R&D among all industries. Research and development spending in the pharmaceutical industry around the world is increasing over time. However, there have been variations in the growth of research and development spending, with a peak during the pandemic years 2020 and 2021.
New pharmaceutical products
The goal of R&D is to produce new drugs and compounds. Globally, the U.S. pharmaceutical industry created the largest number of new drugs and compounds between 2019 and 2023, followed by Europe. Among U.S. pharmaceutical companies, there are various levels of success for new drugs, depending on the phase of development. The data show that between phases I and II alone, already over half of all drugs are failing.