Promonocyte

A promonocyte (or premonocyte) is a cell arising from a monoblast and developing into a monocyte.

Introduction

A promonocyte is an intermediate precursor cell in the monocyte lineage between monoblasts and monocytes, and plays a critical role in immune function and hematopoiesis.

Development and Differentiation

Promonocytes develop from monoblasts in the bone marrow and mature into monocytes, which differentiate into macrophages and dendritic cells.

Morphology

Promonocytes are characterized by distinct cytological features that distinguish them from both monoblasts and mature monocytes.

Immunophenotype

Promonocytes can be identified by their specific surface marker expression via immunophenotyping, which reflects their transitional stage in monocyte development.

Role in Hematopoiesis

Promonocytes are a key transitional cell type ensuring continuous production of monocytes for immune system maintenance.

Clinical Significance

The presence and identification of promonocytes are clinically important in hematological diagnostics and disease classification.

Emerging Diagnostic Approaches

Advances in computational and imaging methods are being developed to improve the recognition of promonocytes.

Research Applications

Promonocytes are studied in immunology and oncology to better understand monocyte development and leukemogenesis.

• Pluripotential hemopoietic stem cell

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  Hematopoiesis
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  Schematic image of a promonocyte

• "Monocyte Development" at tulane.edu
• Slide at marist.edu
• Histology image: 75_17 at the University of Oklahoma Health Sciences Center - "Bone marrow smear"
• "Maturation Sequence" at hematologyatlas.com (Promonocyte is in seventh row.)

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