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Wolfram Language & System Documentation Center
BioSequenceModify
  • See Also
    • BioSequence
    • BioSequenceTranslate
    • BioSequenceBackTranslateList

    • Entity Types
    • GeneticTranslationTable
  • Related Guides
    • Biomolecular Sequences
    • See Also
      • BioSequence
      • BioSequenceTranslate
      • BioSequenceBackTranslateList

      • Entity Types
      • GeneticTranslationTable
    • Related Guides
      • Biomolecular Sequences

BioSequenceModify[seq,"mod"]

gives the result of applying the modification "mod" to the sequence seq.

BioSequenceModify[seq,{"mod",params}]

specifies the parameters params for "mod".

BioSequenceModify[modspec]

represents an operator form of BioSequenceModify that can be applied to a biomolecular sequence.

Details
Details and Options Details and Options
Examples  
Basic Examples  
Scope  
"AddBond"  
"AddToCollection"  
Show More Show More
"CanonicalRepresentation"  
"DeleteBond"  
"DropToStartCodon"  
"InnermostBondRepresentation"  
"MakeCircular"  
"MakeLinear"  
"OutermostBondRepresentation"  
"SplitDisconnectedCollection"  
Applications  
Possible Issues  
Neat Examples  
See Also
Related Guides
History
Cite this Page
BUILT-IN SYMBOL
  • See Also
    • BioSequence
    • BioSequenceTranslate
    • BioSequenceBackTranslateList

    • Entity Types
    • GeneticTranslationTable
  • Related Guides
    • Biomolecular Sequences
    • See Also
      • BioSequence
      • BioSequenceTranslate
      • BioSequenceBackTranslateList

      • Entity Types
      • GeneticTranslationTable
    • Related Guides
      • Biomolecular Sequences

BioSequenceModify

BioSequenceModify[seq,"mod"]

gives the result of applying the modification "mod" to the sequence seq.

BioSequenceModify[seq,{"mod",params}]

specifies the parameters params for "mod".

BioSequenceModify[modspec]

represents an operator form of BioSequenceModify that can be applied to a biomolecular sequence.

Details

  • Bond modifications:
  • {"AddBond",{i1,i2}}add a higher-order bond between letters at i1 and i2
    {"AddBond",Bond[{i1,i2},"type"]}add a bond of the given type between the given indices
    {"DeleteBond",{i1,i2}}remove all higher-order bonds between the given indices
    {"DeleteBond",Bond[{i1,i2},"type"]}remove the specified bond between the given indices
  • Circularity adjustment modifications:
  • "MakeCircular"convert a linear sequence into a circular sequence
    "MakeLinear"convert a circular sequence into a linear sequence
    {"MakeLinear",i}convert to a linear sequence, starting at the i^(th) position
  • Collection modifications:
  • {"AddToCollection",{seq1,seq2,…}}incorporate a list of sequences into a sequence collection
    "SplitDisconnectedCollection"separate unbonded clusters into separate collections
  • Representation-only modifications:
  • "InnermostBondRepresentation"represent bonds at the innermost applicable sequence
    "OutermostBondRepresentation"represent bonds at the outermost sequence
    "CanonicalRepresentation"convert all sequences and bonds to a canonical form
  • Translation modifications:
  • "DropIncompleteCodons"drop incomplete codons from the end of DNA or RNA
    "DropToStartCodon"drop letters from DNA or RNA until a start codon is found
    "DropFromStopLetter"drop the letters from a peptide after a stop letter is found

Examples

open all close all

Basic Examples  (5)

Add a bond to a sequence:

Delete a bond from a sequence:

Represent all bonds at the innermost sequence, with all letters included:

Represent all bonds at the outermost sequence:

Canonicalize the representation of bonds and sequences into a sorted and reduced form:

Scope  (30)

Convert a linear sequence to a circular sequence:

Convert a circular sequence to a linear sequence:

Add a list of sequences into a sequence collection:

Separate the unbound components of a sequence collection into separate collections:

Drop letters at the end of a nucleotide sequence so only complete codons are present for translation:

Drop the letters up to a start codon in the default genetic translation table:

Drop terms after the stop letter in a peptide sequence:

"AddBond"  (4)

A bond type does not need to be specified to insert a bond. If one is not given, it will be inferred:

The type of the bond inferred may depend on the letters being linked:

Bonds can be added to hybrid strands:

Bonds can be added to sequence collections:

"AddToCollection"  (3)

A single sequence can also be added to a collection:

A single motif or hybrid sequence will be modified into a collection:

If there are multiple sequence collections, they will be merged in the result:

"CanonicalRepresentation"  (3)

If sequences are identical, canonicalization will use strand-level bonds for ordering:

If the sequences and strand-level bonds are identical, canonicalization will use sequence bonds for ordering:

In addition to sorting, single-strand collections are reduced to the strand and single motif hybrids are reduced to the motif:

"DeleteBond"  (2)

Delete all higher-order bonds between the two indexes:

Deleting bonds always works on the outermost form, which is the form given by the "SequenceBondList" property:

"DropToStartCodon"  (3)

Any genetic translation table entity can be used to specify start codons:

A specific codon or list of codons can be used as the start codon specification:

Modifications can be created in an operator form:

Modifications with further specifications can also be used in operator form:

"InnermostBondRepresentation"  (1)

Moving bonds inward can potentially bring them into the motif from several layers:

"MakeCircular"  (2)

RNA sequences can be converted to circular RNA sequences:

Peptide sequences can be converted to circular peptide sequences:

"MakeLinear"  (3)

Circular RNA sequences can be converted to linear RNA sequences:

Circular peptide sequences can be converted to linear peptide sequences:

Start the linear sequence from a specific position:

Relative bond positions are preserved when converting circular sequences to linear sequences:

"OutermostBondRepresentation"  (1)

Moving bonds inward will bring them from inside any motif or strand to the outermost sequence structure:

"SplitDisconnectedCollection"  (1)

Splitting connections will renumber bonds based on new collection memberships:

Applications  (1)

A circular peptide:

Various peptides can be related to each other through a circular permutation:

Possible Issues  (2)

A given modification may not apply to a particular type of sequence:

If a bond type cannot be inferred, an untyped bond is added:

Neat Examples  (1)

Represent the protein preproinsulin as a BioSequence:

Remove the signal peptide sequence to make proinsulin:

Add the disulfide bonds and split the proinsulin sequence to make insulin:

See Also

BioSequence  BioSequenceTranslate  BioSequenceBackTranslateList

Entity Types: GeneticTranslationTable

Function Repository: BuildBioSequenceBondListFromFoldingMatrix

Related Guides

    ▪
  • Biomolecular Sequences

History

Introduced in 2020 (12.2) | Updated in 2021 (13.0)

Wolfram Research (2020), BioSequenceModify, Wolfram Language function, https://reference.wolfram.com/language/ref/BioSequenceModify.html (updated 2021).

Text

Wolfram Research (2020), BioSequenceModify, Wolfram Language function, https://reference.wolfram.com/language/ref/BioSequenceModify.html (updated 2021).

CMS

Wolfram Language. 2020. "BioSequenceModify." Wolfram Language & System Documentation Center. Wolfram Research. Last Modified 2021. https://reference.wolfram.com/language/ref/BioSequenceModify.html.

APA

Wolfram Language. (2020). BioSequenceModify. Wolfram Language & System Documentation Center. Retrieved from https://reference.wolfram.com/language/ref/BioSequenceModify.html

BibTeX

@misc{reference.wolfram_2025_biosequencemodify, author="Wolfram Research", title="{BioSequenceModify}", year="2021", howpublished="\url{https://reference.wolfram.com/language/ref/BioSequenceModify.html}", note=[Accessed: 01-May-2026]}

BibLaTeX

@online{reference.wolfram_2025_biosequencemodify, organization={Wolfram Research}, title={BioSequenceModify}, year={2021}, url={https://reference.wolfram.com/language/ref/BioSequenceModify.html}, note=[Accessed: 01-May-2026]}

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