FOS

FOS
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A02, 1FOS, 1S9K
Dynodwyr
Cyfenwau	FOS, AP-1, C-p55, Fos proto-oncogene, AP-1 transcription factor subunit
Dynodwyr allanol	OMIM: 164810 HomoloGene: 3844 GeneCards: FOS
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • R-SMAD binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • chromatin binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • double-stranded DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cytosol • bilen • transcription regulator complex • nucleoplasm • Reticwlwm endoplasmig • neuron projection • cnewyllyn cell • protein-DNA complex • transcription factor AP-1 complex Prosesau biolegol • cellular response to extracellular stimulus • response to muscle stretch • response to immobilization stress • cellular response to calcium ion • response to cytokine • GO:0009373 regulation of transcription, DNA-templated • SMAD protein signal transduction • GO:1904578 response to organic cyclic compound • response to light stimulus • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • response to progesterone • female pregnancy • response to corticosterone • response to mechanical stimulus • GO:0010260 heneiddio • positive regulation of osteoclast differentiation • transcription by RNA polymerase II • nervous system development • GO:0072353 cellular response to reactive oxygen species • response to gravity • Fc-epsilon receptor signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • DNA methylation • response to lipopolysaccharide • Cwsg • cellular response to hormone stimulus • regulation of DNA-binding transcription factor activity • conditioned taste aversion • skeletal muscle cell differentiation • response to cold • response to cAMP • inflammatory response • transforming growth factor beta receptor signaling pathway • positive regulation of pri-miRNA transcription by RNA polymerase II • response to toxic substance • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of gene expression • cytokine-mediated signaling pathway • cellular response to cadmium ion • positive regulation of neuron death Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2353	n/a
Ensembl	ENSG00000170345	n/a
UniProt	P01100 Q6FG41	n/a
RefSeq (mRNA)	NM_005252	n/a
RefSeq (protein)	NP_005243 NP_005243.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FOS yw FOS a elwir hefyd yn Proto-oncogene c-Fos a FOS protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q24.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FOS.

• p55
• AP-1
• C-FOS

• "NF-Y Binding Site Architecture Defines a C-Fos Targeted Promoter Class. ". PLoS One. 2016. PMID 27517874.
• "MicroRNA-101 inhibits the proliferation and invasion of bladder cancer cells via targeting c-FOS. ". Mol Med Rep. 2016. PMID 27485165.
• "CRAC channels are required for [Ca(2+)]i oscillations and c-fos gene expression after muscarinic acetylcholine receptor activation in leukemic T cells. ". Life Sci. 2016. PMID 27474128.
• "Evidence for Homodimerization of the c-Fos Transcription Factor in Live Cells Revealed by Fluorescence Microscopy and Computer Modeling. ". Mol Cell Biol. 2015. PMID 26303532.
• "Fusion events lead to truncation of FOS in epithelioid hemangioma of bone.". Genes Chromosomes Cancer. 2015. PMID 26173738.