• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Pakistan Journal of Biological Sciences
  2. Vol 15 (16), 2012
  3. 754-774
  • Issues
    Online First Current Issue All Issues
  • Information About
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Pakistan Journal of Biological Sciences

Year: 2012 | Volume: 15 | Issue: 16 | Page No.: 754-774
DOI: 10.3923/pjbs.2012.754.774

Facebook Twitter Reddit Linkedin E-mail
Google Scholar ASCI
Review Article

Immunomodulatory and Therapeutic Potentials of Herbal, Traditional/Indigenous and Ethnoveterinary Medicines

Mahima
Department of Animal Nutrition, Uttar Pradesh Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishvidhyalaya Ewam Go-Anusandhan Sansthan (DUVASU), Mathura, 281001, India

Anu Rahal
Department of Veterinary Pharmacology and Toxicology, Uttar Pradesh Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishvidhyalaya Ewam Go-Anusandhan Sansthan (DUVASU), Mathura, 281001, India

Rajib Deb
Animal Genetics and Breeding, Project Directorate on Cattle, Indian Council of Agricultural Research, Grass farm Road, Meerut, Uttar Pradesh-250001, India

Shyma K. Latheef
Immunology Section, Indian Veterinary Research Institute, Izatnagar, India

Hari Abdul Samad
Division of Animal Physiology and Climatology, Indian Veterinary Research Institute, Izatnagar, India

Ruchi Tiwari
Department of Veterinary Microbiology and Immunology, Uttar Pradesh Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishvidhyalaya Ewam Go-Anusandhan Sansthan (DUVASU), Mathura, 281001, India

Amit Kumar Verma
Department of Veterinary Epidemiology and Preventive Medicine, Uttar Pradesh Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishvidhyalaya Ewam Go-Anusandhan Sansthan (DUVASU), Mathura, 281001, India

Amit Kumar
Department of Veterinary Microbiology and Immunology, Uttar Pradesh Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishvidhyalaya Ewam Go-Anusandhan Sansthan (DUVASU), Mathura, 281001, India

K. Dhama
Division of Pathology, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, India

Herbs/Botanical plants are considered as God’s gift to human beings in the form of natural medicines, like the one well known “Sanjeevani booti” described in Hindu Mythology. The traditional and ethno-veterinary practices have been in use for centuries, transferring the knowledge from generation to generation and they are accessible, easy to prepare and administer, with little or no cost at all. Even though the modern developments in therapeutic field brought about a rapid decline in traditional medicine, the plant-based remedies are still having a crucial role as potential source of therapeutic aids in health systems all over the world for both humans and animals. Among the 21,000 medicinal plants listed by the World Health Organization (WHO), 2500 species are native to India, which stands first in the production of medicinal herbs. This innumerable treasure of medicinal herbs brings India the distinction of ‘the botanical garden of the world’. Nowadays immune-based therapies are gaining more importance than monovalent approaches which are having limited benefits. Apart from the actions like treating diseases, control of ecto- and endo-parasites, fertility enhancement, bone setting and poor mothering management, an array of herbal medicines have been reported which are having immunomodulatory effects like modulation of cytokine secretion, histamine release, immunoglobulin secretion, class switching, cellular co-receptor expression, lymphocyte expression, phagocytosis and so on. The present article describes in brief few of these important ones viz., ashwagandha, amla, tulsi, arjuna, aloe vera, garlic, turmeric, ginger, shatavari, neem, guduchi, kiwifruit, tut, kamala, palashlata, kokilaksha etc. being used for human and animal health benefits.
PDF Fulltext XML References Citation

How to cite this article

Mahima, Anu Rahal, Rajib Deb, Shyma K. Latheef, Hari Abdul Samad, Ruchi Tiwari, Amit Kumar Verma, Amit Kumar and K. Dhama, 2012. Immunomodulatory and Therapeutic Potentials of Herbal, Traditional/Indigenous and Ethnoveterinary Medicines. Pakistan Journal of Biological Sciences, 15: 754-774.

DOI: 10.3923/pjbs.2012.754.774

URL: https://scialert.net/abstract/?doi=pjbs.2012.754.774

Related Articles

Phytochemistry, Modes of Action and Beneficial Health Applications of Green Tea (Camellia sinensis) in Humans and Animals
Avian Egg Yolk Antibodies (IgY) and their Potential Therapeutic Applications for Countering Infectious Diseases of Fish and Aquatic Animals
Nutritional and Healthical Aspects of Spirulina (Arthrospira) for Poultry, Animals and Human
Plants as Future Source of Anti-Mycobacterial Molecules and Armour for Fighting Drug Resistance
Immunomodulatory and Protective Effects of a Polyherbal Formulation (Immon) Against Infectious Anemia Virus Infection in Broiler
Indian Medicinal Plants: A Rich Source of Natural Immuno-Modulator
Herbal Plants as New Immuno-stimulator in Poultry Industry: A Review
Isolation, Characterization and Antibiogram of Mycoplasma bovis in Sheep Pneumonia
Prevalence and Antibiogram of Campylobacter Infections in Dogs of Mathura, India
Veterinarian for the Sustainable Development of the Humanity

Leave a Comment


Your email address will not be published. Required fields are marked *

Article Trend



Total views 14182

References


  1. Ablise, M., B. Leininger-Muller, C.D. Wong, G. Siest, V. Loppinet and S. Visvikis, 2004. Synthesis and in vitro antioxidant activity of glycyrrhetinic acid derivatives tested with the cytochrome P450/NADPH system. Chem. Pharm. Bull., 52: 1436-1439.
    CrossRefPubMedDirect Link

  2. Agarwal, M., S. Walia, S. Dhingra and B.P. Khambay, 2001. Insect growth inhibition, antifeedant and antifungal activity of compounds isolated/derived from Zingiber officinale Roscoe (ginger) rhizomes. Pest Manage. Sci., 57: 289-300.
    CrossRefPubMedDirect Link

  3. Ahmad, A.H., A. Rahal and A. Tripathi, 2006. Optimising drug potential of plants. Proceedings of the Symposium on Recent Trends in Development of Herbal Drugs: Challenges and Opportunities and 6th Annual Conference of ISVPT, November 23-25, 2006, Ranchi, India, pp: 9-9.

  4. Ahmed, A.A., N.I. Bassuony, S.E.H.S. Awad, A.M. Aiad and S.A. Mohamed, 2009. Adding natural juice of vegetables and fruitage to ruminant diets (B) nutrients utilization, microbial safety and immunity, effect of diets suplemented with lemon, onion and garlic juice fed to growing buffalo calves. World J. Agric. Sci., 5: 456-465.
    Direct Link

  5. Akamatsu, H., J. Komura, Y. Asada and Y. Niwa, 1991. Mechanism of anti-inflammatory action of glycyrrhizin: Effect on neutrophil functions including reactive oxygen species generation. Planta Med., 57: 119-121.
    CrossRefPubMed

  6. Akhtar, M.S., Z. Iqbal, M.N. Khan and M. Lateef, 2000. Anthelmintic activity of medicinal plants with particular reference to their use in animals in Indo-Pakistan subcontinent. Small Rumin. Res., 38: 99-107.
    CrossRefDirect Link

  7. Alzoreky, N.S. and K. Nakahara, 2003. Antibacterial activity of extracts from some edible plants commonly consumed in Asia. Int. J. Food Microbiol., 80: 223-230.
    CrossRefPubMedDirect Link

  8. Aranha, I., F. Clement and Y.P. Venkatesh, 2012. Immunostimulatory properties of the major protein from the stem of the Ayurvedic medicinal herb, guduchi (Tinospora cordifolia). J. Ethnopharmacol., 139: 366-372.
    CrossRef

  9. Archana, S.J., R. Paul and A. Tiwari, 2011. Indian medicinal plants: A rich source of natural immuno-modulator. Int. J. Pharmacol., 7: 198-205.
    CrossRefDirect Link

  10. Awodele, O., S.O. Olayemi, T.A. Adeyemo, T.A. Sanya and D.C. Dolapo, 2012. Use of complementary medicine amongst patients on antiretroviral drugs in an HIV treatment centre in Lagos, Nigeria. Curr. Drug Saf., 7: 120-125.
    CrossRefPubMedDirect Link

  11. Bachiega, T.F., J.P.B. de Sousa, J.K. Bastos and J.M. Sforcin, 2012. Clove and eugenol in noncytotoxic concentrations exert immunomodulatory/anti-inflammatory action on cytokine production by murine macrophages. J. Pharm. Pharmacol., 64: 610-616.
    CrossRefDirect Link

  12. Baliga, M.S. and J.J. Dsouza, 2011. Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. Eur. J. Cancer Prev., 20: 225-239.
    CrossRefPubMed

  13. Belinky, P.A., M. Aviram, S. Mahmood and and J. Vaya, 1998. Structural aspects of the inhibitory effect of glabridin on LDL oxidation. Free Radical Biol. Med., 24: 1419-1429.
    CrossRef

  14. Belska, N.V., A.M. Guriev, M.G. Danilets, E.S. Trophimova and E.G. Uchasova et al., 2010. Water-soluble polysaccharide obtained from Acorus calamus L. classically activates macrophages and stimulates Th1 response. Int. Immunopharmacol., 10: 933-942.
    CrossRef

  15. Bensky, D. and A. Gamble, 1993. Chinese Herbal Medicine: Materia Medica. Eastland Press Inc., Seattle, USA.

  16. Bharani, S.E., M. Asad, S.S. Dhamanigi and G.K. Chandrakala, 2010. Immunomodulatory activity of methanolic extract of Morus alba Linn. (mulberry) leaves. Pak. J. Pharm. Sci., 23: 63-68.
    Direct Link

  17. Bharavi, K., A.G. Reddy, G.S. Rao, A.R. Reddy and S.V. Rao, 2010. Reversal of cadmium-induced oxidative stress in chicken by herbal adaptogens Withania somnifera and Ocimum sanctum. Toxicol. Int., 17: 59-63.
    CrossRefPubMed

  18. Blecha, F., 2001. Immunomodulators for prevention and treatment of infectious diseases in food-producing animals. Vet. Clin. North Am. Food Anim. Pract., 17: 621-633.
    PubMed

  19. Blumenthal, M., 2004. Echinacea trial. Altern. Ther. Health Med., 10: 12-14.
    PubMed

  20. Boehm, K., A. Bussing and T. Ostermann, 2012. Aromatherapy as an adjuvant treatment in cancer care: A descriptive systematic review. Afr. J. Traditional Complementary Altern. Med., 9: 503-518.
    Direct Link

  21. Borsuk, O.S., N.V. Masnaya, E.Y. Sherstoboev, N.V. Isaykina, G.I. Kalinkina and D.V. Reihart, 2011. Effects of drugs of plant origin on the development of the immune response. Bull. Exp. Biol. Med., 151: 194-196.
    CrossRefDirect Link

  22. Burton Goldberg Group, 1999. Alternative Medicine: The Definitive Guide. Future Medicine Publishing, Tiburon, CA., USA., ISBN-13: 9781887299336 pp: 263.

  23. Chang, Y.P., C.H. Liu, C.C. Wu, C.M. Chiang, J.L. Lian and S.L. Hsieh, 2012. Dietary administration of zingerone to enhance growth, non-specific immune response and resistance to Vibrio alginolyticus in Pacific white shrimp (Litopenaeus vannamei) juveniles. Fish Shellfish Immunol., 32: 284-290.
    CrossRefPubMed

  24. Chauhan, R.S., 2010. Nutrition, immunity and livestock health. Indian Cow: Scient. Econ. J., 7: 2-13.
    Direct Link

  25. Cherng, J.M., W. Chiang and L.C. Chiang, 2008. Immunomodulatory activities of common vegetables and spices of Umbelliferae and its related coumarins and flavonoids. Food Chem., 106: 944-950.
    CrossRefDirect Link

  26. Cho, W.C. and K.N. Leung, 2007. In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus. J. Ethnopharmacol., 113: 132-141.
    PubMed

  27. Chopra, R.N., 1982. Indigenous Drugs of India. 2nd Edn., Academic Publishers, Calcutta.

  28. Desai, V.R., R. Ramkrishnan, G.J. Chintalwar and K.B. Sainis, 2007. G1-4A, an immunomodulatory polysaccharide from Tinospora cordifolia, modulates macrophage responses and protects mice against lipopolysaccharide induced endotoxic shock. Int. Immunopharmacol., 7: 1375-1386.
    CrossRef

  29. Devasagayam, T.P.A., J.P. Kamat and N. Sreejayan, 2001. Antioxidant Action of Curcumin. In: Micronutrients and Health: Molecular Biological Mechanisms, Nesaretnam, K. and L. Packer (Eds.). AOCS Press, USA, pp: 42-59.

  30. Dhama, K., T. Ruchi, R. Barathidasan and S.D. Singh, 2012. Novel immunomodulatory and therapeutic approaches for combating viral diseases of poultry: The perspectives. Proceedings of the 21st National Conference of Indian Virological Society, November 8-10, 2012, Uttarakhand, India, pp: 146-155.

  31. Dhankhar, S., S. Dhankhar, M. Kumar, S. Ruhil, M. Balhara and A.K. Chhillar, 2012. Analysis toward innovative herbal antibacterial and antifungal drugs. Recent Pat. Antiinfect. Drug Discov., 7: 242-248.
    CrossRefPubMed

  32. Ding, X., F. Zhu and S. Gao, 2012. Purification, antitumour and immunomodulatory activity of water-extractable and alkali-extractable polysaccharides from Solanum nigrum L. Food Chem., 131: 677-684.
    CrossRef

  33. Ebadi, M., 2002. Pharmacodynamic Basis of Herbal Medicines. CRC Press, Washington, DC.

  34. Efferth, T., P.C.H. Li, V.S.B. Konkimalla and B. Kaina, 2007. From traditional Chinese medicine to rational cancer therapy. Trends Mol. Med., 13: 353-361.
    CrossRefPubMed

  35. Egger, S.F., G.S. Brown, L.S. Kelsey, K.M. Yates, L.J. Rosenberg and J.E. Talmadge, 1996. Studies on optimal dose and administration schedule of a hematopoietic stimulatory beta-(1,4)-linked mannan. Int. J. Immunopharmacol., 18: 113-126.
    CrossRefPubMed

  36. Feng, Y., X. Zhu, Q. Wang, Y. Jiang, H. Shang, L. Cui and Y. Cao, 2012. Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection. Malaria J., Vol. 11.
    CrossRef

  37. Ganguly, S. and A. Prasad, 2011. Role of plant extracts and cow urine distillate as immunomodulators: A review. J. Med. Plant Res., 5: 649-651.
    Direct Link

  38. Ganju, L., D. Karan, S. Chanda, K.K. Srivastava, R.C. Sawhney and W. Selvamurthy, 2003. Immunomodulatory effects of agents of plant origin. Biomed. Pharmacother., 57: 296-300.
    CrossRefDirect Link

  39. Guatam, M., S. Diwanay, S. Gairola, Y.S. Shinde, P. Patki and B. Patwardhan, 2004. Immunoadjuvant potential of Asparagus racemosus aqeous extract in experimental system. J. Ethnopharmacol., 91: 251-255.
    PubMed

  40. Gautam, M., S. Saha, S. Bani, A. Kaul and S. Mishra et al., 2009. Immunomodulatory activity of Asparagus racemosus on systemic Th1/Th2 immunity: Implications for immunoadjuvant potential. J. Ethnopharmacol., 121: 241-247.
    CrossRefPubMedDirect Link

  41. Goyal, B.M., P. Bansal, V. Gupta, S. Kumar, R. Singh and M. Maithani, 2010. Pharmacological potential of Boerhaavia diffusa: An overview. Int. J. Pharm. Sci. Drug Res., 2: 17-22.
    Direct Link

  42. Guo, N.L., D.P. Lu, G.L. Woods, E. Reed, G.Z. Zhou, L.B. Zhang and R.H. Waldman, 1993. Demonstration of the anti-viral activity of garlic extract against human cytomegalovirus in vitro. Chinese Med. J., 106: 93-96.
    PubMedDirect Link

  43. Gupta, A., A. Khajuria, J. Singh, K.L. Bedi and N.K. Satti et al., 2006. Immunomodulatory activity of biopolymeric fraction RLJ-NE-205 from Picrorhiza kurroa. Int. Immunopharmacol., 6: 1543-1549.
    CrossRef

  44. Gupta, S.K., J. Prakash and S. Srivastava, 2002. Validation of claim of Tulsi, Ocimum sanctum Linn. as a medicinal plant. Indian J. Exp. Biol., 40: 765-773.
    PubMed

  45. Halder, S., A.K. Mehta and P.K. Mediratta, 2012. Augmented humoral immune response and decreased cell-mediated immunity by Aloe vera in rats. Inflammopharmacology, 20: 343-346.
    CrossRefPubMed

  46. Halder, S., A.K. Mehta, P.K. Mediratta and K.K. Sharma, 2011. Essential oil of clove (Eugenia caryophyllata) augments the humoral immune response but decreases cell mediated immunity. Phytother. Res., 25: 1254-1256.
    CrossRefPubMed

  47. Hashemi, S.R. and H. Davoodi, 2012. Herbal plants as new immuno-stimulator in poultry industry: A review. Asian J. Anim. Vet. Adv., 7: 105-116.
    CrossRefDirect Link

  48. Hong, Q., D.E. Minter, S.G. Franzblau, M. Arfan, H. Amin and M.G. Reinecke, 2010. Anti-tuberculosis compounds from Mallotus philippinensis. Nat. Prod. Commun., 5: 211-217.
    PubMed

  49. Hussain, E.H.M.A., K. Jamil and M. Rao, 2001. Hypoglycaemic, hypolipidemic and antioxidant properties of tulsi (Ocimum sanctum Linn.) on streptozotocin induced diabetes in rats. Indian J. Clin. Biochem., 16: 190-194.
    CrossRef

  50. Iranshahy, M. and M. Iranshahi, 2011. Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin): A review. J. Ethnopharmacol., 134: 1-10.
    CrossRefPubMedDirect Link

  51. Cho, J.Y., A.R. Kim, E.S. Yoo, K.U. Baik and M.H. Park, 2002. Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation. Planta Med., 68: 497-500.
    CrossRefPubMedDirect Link

  52. Jo, E.H., H.D. Hong, N.C. Ahn, J.W. Jung and S.R. Yang et al., 2004. Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell. J. Agric. Food Chem., 52: 1715-1719.
    CrossRefPubMedDirect Link

  53. Kamiyama, H., S. Takano, E. Ishikawa, K. Tsuboi and A. Matsumura, 2005. Anti-angiogenic and immunomodulatory effect of the herbal medicine Juzen-taiho-to on malignant glioma. Biol. Pharm. Bull., 28: 2111-2116.
    PubMed

  54. Kannan, M., A.J.A.R. Singh, T.A. Kumar, P. Jegatheswari and S. Subburayalu, 2007. Studies on immunobioactivities of Nyctanthes arbortristis (Oleaceae). Afr. J. Microbiol. Res., 1: 88-91.
    Direct Link

  55. Kim, S.B., B.Y. Chang, Y.H. Jo, S.H. Lee and S.B. Han et al., 2013. Macrophage activating activity of pyrrole alkaloids from Morus alba fruits. J. Ethnopharmacol., 145: 393-396.
    CrossRef

  56. Kumar A., A.K. Verma, Parul and V.P. Singh, 2011. Prevalence and antibiotic profile of bacterial isolates in chicken meat in Western U.P. J. Vet. Pub. Health, 9: 111-114.

  57. Kumar, A., A.K. Verma, N.K. Gangwar and A. Rahal, 2012. Isolation, characterization and antibiogram of Mycoplasma bovis in sheep pneumonia. Asian J. Anim. Vet. Adv., 7: 149-157.
    CrossRefDirect Link

  58. Kumar, R., A.K. Verma, A. Kumar, M. Srivastava and H.P. Lal, 2012. Prevalence and antibiogram of campylobacter infections in dogs of Mathura, India. Asian J. Anim. Vet. Adv., 7: 434-440.
    CrossRefDirect Link

  59. Kumar, R.A., K. Sridevi, N.V. Kumar, S. Nanduri and S. Rajagopal, 2004. Anticancer and immunostimulatory compounds from Andrographis paniculata. J. Ethnopharmcol., 92: 291-295.
    CrossRefDirect Link

  60. Kushwaha, S., S. Roy, R. Maity, A. Mallick and V.K. Soni et al., 2012. Chemotypical variations in Withania somnifera lead to differentially modulated immune response in BALB/c mice. Vaccine, 30: 1083-1093.
    CrossRef

  61. Kwon, Y.S., K.H. Jang and I.H. Jang, 2003. The effects of Korean red ginseng (Ginseng radix Rubra) on liver regeneration after partial hepatectomy in dogs. J. Vet. Sci., 4: 83-92.
    PubMedDirect Link

  62. Lai, P.F. and H.Y. Zhang, 2002. Research progress of Maorenshen (Radix Actinidiae Macrospermae): A habitually used traditional Chinese herbal drug in Zhejiang province of China. Zhejiang Zhong Yi Xue Yuan Xue Bao., 26: 77-78.

  63. Lambey, H.S., A.K. Verma, U. Jain, Mahima and B. Bist, 2009. Bacteriological quality of chevon and pork in Mathura city. J. Vet. Public Health, 7: 141-143.
    Direct Link

  64. Li, J., Q.W. Li, D.W. Gao, Z.S. Han and W.Z. Lu, 2009. Antitumor and immunomodulating effects of polysaccharides isolated from Solanum nigrum L. Phytother. Res., 23: 1524-1530.
    CrossRef

  65. Lorenzetti, L.J., R. Salisbury, J.L. Beal and J.N. Baldwin, 1964. Bacteriostatic property of Aloe vera. J. Pharm. Sci., 53: 1287-1287.
    CrossRef

  66. Lu, Y., J. Fan, Y. Zhao, S. Chen, X. Zheng, Y. Yin and C. Fu, 2007. Immunomodulatory activity of aqueous extract of Actinidia macrosperma. Asia Pac. J. Clin. Nutr., 16: 261-265.

  67. Mahima, A.K. Verma, A. Kumar, V. Kumar and A. Rahal, 2012. Designer milk for human health: A future need. Int. J. Dairy Sci., 7: 70-72.
    CrossRefDirect Link

  68. Mahima, A.K. Verma, A. Kumar, V. Kumar and A. Rahal, 2012. Designer egg: Future prospects. Asian J. Poult. Sci., 6: 97-100.
    CrossRef

  69. Mahima, A.K. Verma, A. Kumar, V. Kumar and D. Roy, 2012. Scope of biotechnology in animal nutrition. Asian J. Anim. Sci., 6: 316-318.
    CrossRef

  70. Mahima, A.K. Verma, A. Kumar, A. Rahal and V. Kumar, 2012. Veterinarian for the sustainable development of the humanity. Asian J. Anim. Vet. Adv., 7: 452-453.
    CrossRefDirect Link

  71. Mahima, A.K. Verma, A. Kumar, A. Rahal, V. Kumar and D. Roy, 2012. Inorganic versus organic selenium supplementation: A review. Pak. J. Biol. Sci., 15: 418-425.
    CrossRefDirect Link

  72. Majdalawieh, A.F. and R.I. Carr, 2010. In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum). J. Med. Food., 13: 371-381.
    CrossRefPubMedDirect Link

  73. Mathew, T., Z. Mathew and K. Dhama, 2010. Plants and herbs for the treatment of cancer in human and animals. Proceedings of the National Seminar on Advances in Animal Cancer Research in India: Diagnosis, Treatment and Clinical Management, June 15-16, 2010, Indian Veterinary Research Institute, Izatnagar (U.P.)., India Souvenir, pp: 85-86.

  74. Mediratta, P.K., K.K. Sharma and S. Singh, 2002. Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action. J. Ethanopharmacol., 80: 15-20.
    CrossRef

  75. Mehrotra, S., K.P. Mishra, R. Maurya, R.C. Srimal and V.K. Singh, 2002. Immunomodulation by ethanolic extract of Boerhaavia diffusa roots. Int. Immunopharmacol., 2: 987-996.
    CrossRefDirect Link

  76. Mehrotra, S., K.P. Mishra, R. Maurya, R.C. Srimal, V.S. Yadav, R. Pandey and V.K. Singh, 2003. Anticellular and immunosuppressive properties of ethanolic extract of Acorus calamus rhizome. Int. Immunopharmacol., 3: 53-61.
    CrossRefDirect Link

  77. Mills, S. and K. Bone, 2000. Principles and Practice Of Phytotherapy. Churchill Livingstone, Edinburgh, Uk, pp: 34-37.

  78. Mirabeau, T.Y. and E.S. Samson, 2012. Effect of Allium cepa and Allium sativum on some immunological cells in rats. Afr. J. Trad. Complement. Alter. Med., Vol. 9.
    Direct Link

  79. Mishra, L.C., B.B. Singh and S. Dagenais, 2000. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): A review. Altern. Med. Rev., 5: 334-346.
    PubMedDirect Link

  80. Mirzaei-Aghsaghali, A., 2012. Importance of medical herbs in animal feeding: A review. Ann. Biol. Res., 3: 918-923.
    Direct Link

  81. Mondal, S., S. Varma, V.D. Bamola, S.N. Naik and B.R. Mirdha et al., 2011. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. J. Ethnopharmacol., 136: 452-456.
    CrossRefPubMed

  82. Mubarack, H.M., A. Doss, R. Dhanabalan and R. Venkataswamy, 2011. In vitro antimicrobial effects of some selected plants against bovine mastitis pathogens. Hygeia J. D. Med., 3: 71-75.
    Direct Link

  83. Mujtaba, T. and Q.P. Dou, 2012. Black tea polyphenols inhibit tumor proteasome activity. In vivo, 26: 197-202.
    PubMedDirect Link

  84. Mukherjee, D., T.N. Khatua, P. Venkatesh, B.P. Saha and P.K. Mukherjee, 2010. Immunomodulatory potential of rhizome and seed extracts of Nelumbo nucifera Gaertn. J. Ethnopharmacol., 128: 490-494.
    CrossRef

  85. Mungantiwar, A.A., A.M. Nair, U.A. Shinde, V.J. Dikshit, M.N. Saraf, V.S. Thakur and K.B. Sainis, 1999. Studies on the immunomodulatory effects of Boerhaavia diffusa alkaloidal fraction. J. Ethnopharmacol., 65: 125-131.
    CrossRefPubMedDirect Link

  86. Naeini, A.R., A.R. Khosravi, H. Tajbakhsh, T. Ghazanfari and Y. Roya, 2009. Anticandida and immunomodulatory effects of Foeniculum vulgare mill In vitro. Daneshvar Med., 16: 7-20.

  87. Naik, S.R. and A. Hule, 2009. Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata. Planta Medica, 75: 785-791.
    CrossRefPubMedDirect Link

  88. Narayana, M.R. and B.P. Dimri, 1990. Periwinkle and its Cultivation in India. CIMAP, Lucknow, India, Pages: 12.

  89. Ng, T.B., 1998. A review of research on the protein-bound polysaccharide (polysaccharopeptide PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae). Gen. Pharmacol.: Vascular Syst., 30: 1-4.
    CrossRefPubMed

  90. O'Hara, M., D. Kiefer, K. Farrell and K. Kemper, 1998. A review of 12 commonly used medicinal herbs. Arch. Fam. Med., 7: 523-536.
    PubMedDirect Link

  91. Park, S.H., M.S. Kyeong, Y. Hwang, S.Y. Ryu, S.B. Han and Y. Kim, 2012. Inhibition of LPS binding to MD-2 co-receptor for suppressing TLR4-mediated expression of inflammatory cytokine by 1-dehydro-10-gingerdione from dietary ginger. Biochem. Biophys. Res. Commun., 419: 735-740.
    CrossRefPubMed

  92. Patwardhan, B. and M. Gautam, 2005. Botanical immunodrugs: Scope and opportunities. Drug Discov. Today, 10: 495-502.
    CrossRefPubMed

  93. Patwardhan, B., A.D.B. Vaidya and M. Chorghade, 2004. Ayurveda and natural products drug discovery. Curr. Sci., 86: 789-799.
    Direct Link

  94. Pawar, R.S., A.P. Jain, S. Lodhi and A.K. Singhai, 2010. Erythropoietic activity of Asteracantha longifolia (Nees.) in rats. J. Ethnopharmacol., 129: 280-282.
    CrossRefPubMed

  95. Pearson, W., S. Omar and A.F. Clarke, 2007. Low-dose ginseng (Panax quinquefolium) modulates the course and magnitude of the antibody response to vaccination against Equid herpesvirus I in horses. Can. J. Vet. Res., 71: 213-217.
    PubMed

  96. Pettit, G.R., M.S. Hoard, D.L. Doubek, J.M. Schmidt, R.K. Pettit, L.P. Tackett and J.C. Chapuis, 1996. Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae). J. Ethnopharmacol., 53: 57-63.
    CrossRefDirect Link

  97. Prince, P.S., M. Padmanabhan and V.P. Menon, 2004. Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan-induced diabetic liver and kidney. Phytother. Res., 18: 785-787.
    CrossRefPubMedDirect Link

  98. Puri, A., R. Saxena, R.P. Saxena, K.C. Saxena, V. Srivastava and J.S. Tandon, 1994. Immunostimulant activity of Nyctanthes arbortristis L. J. Ethnopharmacol., 42: 31-37.
    Direct Link

  99. Puri, A., R. Saxena, R.P. Saxena, K.C. Saxena, V. Srivastav and J.S. Tandon, 1993. Immunostimulant agents from Andrographis paniculata. J. Nat. Prod., 58: 995-999.
    CrossRefPubMedDirect Link

  100. Pushpangadan, P., 2006. Important Indian Medicinal Plants of Global Interest. Rajiv Gandhi Centre for Biotechnology, Kerala, India, pp: 95-109.

  101. Ragupathi, G., K.S. Yeung, P.C. Leung, M. Lee and C.B. Lau et al., 2008. Evaluation of widely consumed botanicals as immunological adjuvants. Vaccine, 26: 4860-4865.
    CrossRefPubMed

  102. Reghunandan, R., S. Sood, V. Reghunandan, R.M. Mehta and G.P. Singh, 1995. Effect of Ocimum sanctum Linn (Tulsi) extract on testicular function. Indian J. Med. Res., 49: 83-87.
    Direct Link

  103. Reichling, J., J. Fitzi, J. Furst-Jucker, S. Bucher and R. Saller, 2003. Echinacea powder: Treatment for canine chronic and seasonal upper respiratory tract infections. Schweiz. Arch. Tierheilkd., 145: 223-231.
    PubMedDirect Link

  104. Renu, S., N.K. Rakha, G. Sandeep and S.K. Mishra, 2003. Effect of Neem (Azadirachta indica) leaf extract administration on immune responses of broiler chickens. J. Immunol. Immunopathol., 5: 47-50.
    Direct Link

  105. Rios, J.L. and M.C. Recio, 2005. Medicinal plants and antimicrobial activity. J. Ethnopharmacol., 100: 80-84.
    CrossRefPubMedDirect Link

  106. Ross, I.A., 2001. Medicinal Plants of the World: Chemical Constituents, Traditional and Modern Medicinal Uses. Vol. 2, Humana Press, Totowa, New Jersey, ISBN: 9780896038776, Pages: 487.

  107. Roxas, M. and J. Jurenka., 2007. Colds and influenza: A review of diagnosis and conventional, botanical and nutritional considerations. Altern. Med. Rev., 12: 25-48.
    PubMedDirect Link

  108. Ram, M.S., D. Neetu, B. Yogesh, B. Anju and P. Dipti et al., 2002. Cyto-protective and immunomodulating properties of Amla (Emblica officinalis) on lymphocytes: An in-vitro study. J. Ethnopharmacol., 81: 5-10.
    CrossRefDirect Link

  109. Saini, A., S. Sharma and S. Chhibber, 2008. Protective efficacy of Emblica officinalis against Klebsiella pneumoniae induced pneumonia in mice. Indian J. Med. Res., 128: 188-193.
    PubMed

  110. Sandoval, M., R.M. Charbonnet, N.N. Okuhama, J. Roberts, Z. Krenova, A.M. Trentacosti and M.J. Miller, 2000. Cat's claw inhibits TNFα production and scavenges free radicals: Role in cytoprotection. Free Radic. Biol. Med., 29: 71-78.
    Direct Link

  111. Sandoval-Chacoan, M., J.H. Thompson, X.J. Zhang, X. Liu and E.E. Mannick et al., 1998. Antiinflammatory actions of cat's claw: The role of NF-kB. Aliment Pharmacol. Ther., 12: 1279-1289.
    Direct Link

  112. Sane, S.A., N. Shakya and S. Gupta, 2011. Immunomodulatory effect of picroliv on the efficacy of paromomycin and miltefosine in combination in experimental visceral leishmaniasis. Exp. Parasitol., 127: 376-381.
    CrossRef

  113. Jain, S., S. Shrivastava, S. Nayak and S. Sumbhate, 2007. Recent trends in Curcuma longa Linn. Pharmacogn. Rev., 1: 119-128.
    Direct Link

  114. Sen, T., A.K. Dhara, S. Bhattacharjee, S. Pal and A.K. Nag Chaudhuri, 2002. Antioxidant activity of the methanol fraction of Pluchea indica root extract. Phytother. Res., 16: 331-335.
    CrossRefPubMedDirect Link

  115. Sharma, U., M. Bala, N. Kumar, B. Singh, R.K. Munshi and S. Bhalerao, 2012. Immunomodulatory active compounds from Tinospora cordifolia. J. Ethnopharmacol., 141: 918-926.
    CrossRefPubMed

  116. Sharma, J. and R. Varmal, 2011. A review on endangered plant of Mallotus philippensis (Lam.) M.Arg. Pharmacologyonline, 3: 1256-1265.
    Direct Link

  117. Sharma, P., 1983. Chikithsasthana. In: Charaka Samhita, Tripathi, B.N. (Ed.). Chaukhambha Surbharti Publication, Varanasi, India.

  118. Sheng, Y., R.W. Pero and H. Wagner, 2000. Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. Phytomedicine, 7: 137-143.
    CrossRefPubMedDirect Link

  119. Sheng, Y., R.W. Pero, A. Amiri and C. Bryngelsson, 1998. Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa. Anticancer Res., 18: 3363-3368.
    PubMed

  120. Singh, M.K., K. Nagori and D.K. Tripathi, 2010. Potential analgesic and anti-pyretic herbal drugs: A comparative review of marketed products. Int. J. Phytomed., 2: 197-209.

  121. Singh, N., S.M. Singh and P. Shrivastava, 2004. Immunomodulatory and antitumor actions of medicinal plant Tinospora cordifolia are mediated through activation of tumor-associated macrophages. Immunopharmacol. Immunotoxicol., 26: 145-162.
    PubMedDirect Link

  122. Song, J.Y., S.K. Han, E.H. Son, S.N. Pyo, Y.S. Yun, and S.Y. Yi, 2002. Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan. Int. Immunopharmacol., 2: 857-865.
    CrossRefPubMedDirect Link

  123. Spelman, K., J. Burns, D. Nichols, N. Winters, S. Ottersberg and M. Tenborg, 2006. Modulation of cytokine expression by traditional medicines: A review of herbal immunomodulators. Altern. Med. Rev., 11: 128-150.
    PubMedDirect Link

  124. Stuart, R.W., D.L. Lefkowitz, J.A. Lincoln, K. Howard, M.P. Gelderman and S.S. Lefkowitz, 1997. Upregulation of phagocytosis and candicidal activity of macrophages exposed to the immunostimulant, acemannan. Int. J. Immunopharm., 19: 75-82.

  125. Sun, L., H. Zhu, L. Gan, J. Mo, F. Feng and C. Zhou, 2012. [Constituents from the bark of Annona squamosa and their anti-tumor activity]. Zhongguo Zhong Yao Za Zhi, 37: 2100-2104 (In Chinese).
    PubMedDirect Link

  126. Syamala, B., 1997. Asparagus-an antacid and uterine tonic. Science Express dt. 1.7. pp: 8-8.

  127. Szollosi, R., 2011. Indian Mustard (Brassica juncea L.) Seeds in Health. In: Nuts and Seeds in Health and Disease Prevention, Preedy, V.R., R.R. Watsonand and V.B. Patel (Eds.). Academic Press, London, ISBN-13: 9780123756886, pp: 671-676.

  128. Talpur, A.D. and M. Ikhwanuddin, 2013. Azadirachta indica (neem) leaf dietary effects on the immunity response and disease resistance of Asian seabass, Lates calcarifer challenged with Vibrio harveyi. Fish Shellfish Immunol., 34: 254-264.
    CrossRefPubMedDirect Link

  129. Thatte, U.M. and S.A. Dahanukar, 1989. Immunotherapeutic modification of experimental infections by Indian medicinal plants. Phytother. Res., 3: 43-49.
    CrossRefDirect Link

  130. Thatte, U.M. and S.A. Dhanukar, 1997. The Rasayan Concept: Clues from Immunomoldulatory Therapy. In: Immunomodulation, Upadhayaya, S.N. (Ed.). Narosa Publishing House, New Delhi, India, pp: 141-148.

  131. Thatte, U.M., S.G. Rao and S.A. Dahanukar, 1994. Tinospora cordifolia induces colony stimulating activity in serum. J. Postgrad. Med., 40: 202-203.
    PubMedDirect Link

  132. Tilak, J.C. and T.P.A. Devasagayam, 2006. Indian Medicinal Plants: A Potential Reservoir in Health and Disease. In: Contemporary Perspectives on Clinical Pharmacotherapeutics, Kohli, K., M. Gupta and S. Tejwani (Eds.). Elsevier, New Delhi, pp: 29-43.

  133. Tilak, J.C., S. Adhikari and T.P.A. Devasagayam, 2005. Antioxidant Properties of Select Indian Medicinal Plants in Relation to their Therapeutic Effects. In: Molecular Interventions and Protection in Lifestyle Related Diseases, Hiramatsu, M., L. Packer and T. Yoshikawa (Eds.). Taylor and Francis, New York, pp: 303-317.

  134. Toyang, N.J., J. Wanyama, M. Nuwanyakpa and S. Django, 2007. Ethnoveterinary Medicine: A Practical Approach for the Treatment of Cattle Diseases in sub-Saharan Africa. 2nd Edn., Agromisa, The Netherlands, ISBN-13: 9789290813668, Pages: 87.

  135. Tyler, V.E., 1994. Herbs of Choice: The Therapeutic use of Phytomedicinals. Haworth Press, New York, Pages: 209.

  136. Uluisik, D. and E. Keskin, 2012. Effects of ginseng and echinacea on cytokine mRNA expression in rats. Scient. World J.
    CrossRef

  137. Umashanker, M. and S. Shruti, 2011. Traditional Indian herbal medicine used as antipyretic, antiulcer, anti-diabetic and anticancer: A review. Int. J. Res. Pharm. Chem., 1: 1152-1159.
    Direct Link

  138. Upadhayay, H., A. Kuma, A.K. Verma, A. Rahal and S. Mahajan, 2011. Medicinal values of hot aqueous extracts (HAE) of Sonchus Asper (Prickly Sow Thistle) leaves against bacterial and mycotic pathogens. Proceedings of the world congress for man and Nature Global Climate Change and Biodiversity Conservation, November 11-13, 2011, Haridwar, India, Uttarakhand, India, pp: 407-407.

  139. Vaidya, A.D.B. and T.P.A. Devasagayam, 2007. Current status of herbal drugs in India: An overview. J. Clin. Biochem. Nutr., 41: 1-11.
    Direct Link

  140. Valacchi, G., A. Pecorelli, M. Mencarelli, P. Carbotti, V. Fortino, M. Muscettola and E. Maioli, 2009. Rottlerin: A multifaced regulator of keratinocyte cell cycle. Exp. Dermatol., 18: 516-521.
    CrossRef

  141. Verma, A.K., 2005. Cowpathy and human health. Indian Cow: Scient. Econ. J., 2: 39-45.

  142. Verma, A.K., A. Kumar, K. Dhama Mahima and A. Rahal, 2012. Pandemic preparedness for control of influenza viruses. Proceedings of the International Symposium on One Health: Way Forward to Challenges in Food Safety and Zoonoses in 21 Century and th XI Annual Conference of Indian Association of Veterinary Public Health Specialists, December 13-14, 2012, Ludhiana, India.

  143. Verma, A.K., D.K. Sinha and B.R. Singh, 2007. Salmonellosis in apparently healthy dogs. J. Vet. Public Health, 5: 37-39.
    Direct Link

  144. Verma, S. and S.P. Singh, 2008. Current and future status of herbal medicines. Vet. World, 1: 347-350.
    CrossRefDirect Link

  145. Wacker, A. and W. Hilbig, 1978. Virus-inhibition by echinacea purpurea. Planta Med., 33: 89-102. [Article in German].
    PubMedDirect Link

  146. Winkler, C., B. Wirleitner, K. Schroecksnadel, H. Schennach and E. Mur et al., 2004. In vitro effect of two extracts and two pure alkaloid preparations of Uncaria tomentosa and peripheral blood mononuclear cells. Plants Med., 70: 205-210.
    PubMed

  147. Wong, P.Y.Y. and D.D. Kitts, 2006. Studies on the dual antioxidant and antibacterial properties of parsley (Petroselinum crispum) and cilantro (Coriandrum sativum) extracts. Food Chem., 97: 505-515.
    CrossRefDirect Link

  148. Xu, J., X. Song, Z.Q. Yin, A.C. Cheng and R.Y. Jia et al., 2012. Antiviral activity and mode of action of extracts from neem seed kernel against duck plague virus in vitro1. Poult. Sci., 91: 2802-2807.
    Direct Link

  149. Yoshikawa, M., Y. Matsui, H. Kawamoto, N. Umemoto and K. Oku et al., 1997. Effects of glycyrrhizin on immune-mediated cytotoxicity. J. Gastroenterol. Hepatol., 12: 243-248.
    PubMedDirect Link

  150. Yue, Q.X., X.Y. Song, C. Ma, L.X. Feng and S.H. Guan et al., 2010. Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells. Phytomedicine, 17: 606-613.
    PubMedDirect Link

  151. Zhang, L., J. Zhang, B. Zhao and X. Zhao-Wilson, 2012. Quinic acid could be a potential rejuvenating natural compound by improving survival of Caenorhabditis elegans under deleterious conditions. Rejuvenat. Res.
    CrossRefDirect Link

  152. Wangensteen, H., A.B. Samuelsen and K.E. Malterud, 2004. Antioxidant activity in extracts from coriander. Food Chem., 88: 293-297.
    CrossRefDirect Link

  153. Rahal, A. and A. Kumar, 2009. Women's tool towards family health. Proceedings of the 10th Annual Convention of Indian Association of Lady Veterinarians and National Symposium on Contribution of Women Veterinarians in Upliftment of Livestock Production Through New Technologies, January 29-31, 2009, College of Veterinary Sciences and Animal Husbandry, Jabalpur.

  154. Rahal, A. and A. Kumar, 2009. Tulsi: A miracle herb in the hands of traditional house lady. Proceedings of the 10th Annual Convention of Indian Association of Lady Veterinarians and National Symposium on Contribution of Women Veterinarians in Upliftment of Livestock Production Through New Technologies, (CIALV'09), College of Veterinary Sciences and Animal Husbandry, Jawaharlal Nehru Krishi Vishwa Vidyalaya, Jabalpur.

  155. Rajendhran, J., M.A. Mani and K. Navaneethakannan, 1998. Antimicrobial activity of some selected medicinal plants. Geobios, 25: 208-282.

  156. Rege, N.N., U.M. Thatte and S.A. Dahanukar, 1999. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother. Res., 13: 275-291.
    PubMedDirect Link

  157. Sampath Kumar, K.P., D. Bhowmik, S. Duraivel and M. Umadevi, 2012. Traditional and medicinal uses of banana. J. Pharm. Phytochem., 1: 57-70.
    Direct Link

Keywords


  • health
  • disease
  • Herbs
  • immunomodulation
  • ethnoveterinary medicine
  • therapy

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved