How to generate multiple helices instead of one long helix when extending a protein backbone with RFdiffusion？ #414

Hello,

I’m using RFdiffusion to extend the backbone of a protein by approximately 33 amino acids. My goal is for these 33 residues to form at least two helices, but the generated structures always result in one single long helix instead.

Is there any way to guide or constrain RFdiffusion to produce multiple shorter helices rather than a continuous one?
Any suggestions (e.g., input setup) would be greatly appreciated.

Thank you!