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vcf

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A fast, memory-efficient variant effect predictor written in Rust: a from-scratch reimplementation of the Ensembl Variant Effect Predictor (VEP) that takes the same inputs and flags, emits VEP's consequence vocabulary in VEP's output formats, and annotates population-scale callsets two orders of magnitude faster than the Perl implementation.

  • Updated Oct 1, 2026
  • Rust

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