An investigation into the efficacy of treatments for atopic eruption of pregnancy

Atopic eruption of pregnancy (AEP) is a prevalent inflammatory disease in pregnant women and is frequently associated with considerable pruritus and impaired quality of life. There remains an unmet need for reliable tools to predict treatment effectiveness in order to inform and optimize clinical management. In this retrospective cohort study, clinical data from 653 patients diagnosed with AEP at Anhui Maternal and Child Health Hospital between 2009 and 2024 were analyzed. Multivariable regression analyses were performed to identify independent predictors of treatment effectiveness, and a predictive model was subsequently constructed based on these variables. The final model identified histopathological type, allergen screening status, and treatment modality as independent factors associated with treatment effectiveness. The model demonstrated moderate discriminatory capability, with a sensitivity of 81.5% and a specificity of 41.6%. The area under the receiver operating characteristic curve (AUC) was 0.639, reflecting limited predictive accuracy. This predictive model may provide adjunctive support for clinical decision-making in the management of AEP by integrating histopathological findings, allergen screening, and therapeutic approach. However, in light of its moderate predictive performance, the model should be interpreted with caution and applied as a supplementary aid rather than a definitive clinical decision-making tool.

The authors would like to thank each of the women who participated in the study, who have maintained contact with our hospital over the years so that we can observe the safety and effectiveness of the treatment.

This research received funding from the clinical medical research center for obstetrics and gynecology diseases in Qinghai Province(Grant No. 2024-SF-L03).

Authors and Affiliations

1. Qinghai University Affiliated Clinical Medical College, Xining City, Qinghai Province, China

   Xi Ye, Xuanxuan Hong & Fei Wang

2. Obstetrics and Gynecology Department, Qinghai Red Cross Hospital, 55 South Street, Xining, Qinghai Province, China

   Liehong Wang

3. Obstetrics and Gynecology Department, Anhui Province Maternal and Child Health Hospital, Hefei, Anhui, China

   Xiangfeng Zhang, Le Yu & Chenmin Zheng

Corresponding author

Correspondence to Liehong Wang.

Competing interests

The authors declare no competing interests.

Ethics approval and consent to participate

Written informed consent for publication of this paper was obtained from the Medical Ethics Committee of Hefei Maternal and Child Health Hospital (YYLL20240130-YNXM-LL-01-1.7).

Consent for publication

Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

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