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Assessing Generalisation of Perivascular Space Segmentation Across Heterogeneous MRI Cohorts: The DoRA-PVS Challenge 2026
MRI-visible perivascular spaces (PVS) are increasingly recognised as markers of compromised brain health, but their quantitative use requires...
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Signals and Communication Technology
This series is devoted to fundamentals and applications of modern methods of signal processing and cutting-edge communication technologies. The main...
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Extension of the FUNC Score for Prediction of 12-Month Functional Independence after Primary Intracerebral Hemorrhage
Background/ObjectiveThe Functional Outcome in Patients with Primary Intracerebral Hemorrhage (FUNC) score was initially validated for prediction of...
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Defining collectivism as duties in relationships rather than generalized warmth improves predictive validity in 100 cultures
Experts widely agree that East Asian cultures are more collectivistic than Western cultures. Yet 76 survey studies found no reliable difference. Our...
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KRAS and TP53 Circulating Tumor DNA are Prognostic in Localized Pancreatic Cancer
BackgroundPancreatic ductal adenocarcinoma (PDAC) carries high mortality despite neoadjuvant chemotherapy (NAC) and surgical resection, creating an...
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A computational model to describe multi-regional brain architecture during neurodegeneration in Alzheimer’s disease
We previously proposed an MRI-based machine learning model to describe the mesoscopic architecture of the human brain to aid in classifying subjects...
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Assessing subcortical, brainstem and cerebellar metabolic patterns using [18F]FDG PET-CT imaging in dementia with Lewy bodies
PurposeNumerous clinical features of Dementia with Lewy Bodies (DLB) are attributed to dysfunction in subcortical anatomy. Despite this, [18F]FDG...
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Genome-wide association and population-tailored polygenic risk for Parkinson’s disease in Taiwan
Genetic risk factors for Parkinson’s disease (PD) remain under-characterized in East Asian populations. We assembled a Taiwanese case–control cohort...
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Global Educational Inequality Structures, Agency, and Pathways toward Human Rights
Education under globalization becomes a contested terrain: while it can reproduce class hierarchies and epistemic hegemonies, it may also be...
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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegeneration
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves...
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Genetic architecture of lumbar spinal stenosis
Lumbar spinal stenosis (LSS) affects over 100 million people globally, with an increasing incidence due to an ageing population. While LSS is known...
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Acceptability and Feasibility of a Virtual Multimodal (P)Rehabilitation Programme for Gastrointestinal Cancer Patients: The PRIORITY-CONNECT 2 Pilot Randomised Controlled Trial
BackgroundSurgery is a mainstay of treatment for gastrointestinal cancers, yet it often leads to postoperative complications and poorer health...
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GPR146 in adipose tissue drives adipose-liver crosstalk and promotes hepatic steatosis in mice
The limited therapeutic options for metabolic dysfunction-associated steatotic liver disease (MASLD) underscore the need for deeper mechanistic...
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Social and demographic predictors of willingness to participate in an exception from informed consent trial
BackgroundCommunity consultation and public disclosure are key components of exception from informed consent (EFIC) trials, and mandated by the US...
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Sex and APOE genotype specific brain regional vulnerability to Alzheimer's Disease
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex...
