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Prediction of Grade, Gender, and Academic Performance of Children and Teenagers from Handwriting Using the Sigma-Lognormal Model
Digital handwriting acquisition enables the capture of detailed temporal and kinematic signals reflecting the motor processes underlying writing...
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Mammalian recombinant production of mature peptide hormone insulin-like 3 (INSL3)
Insulin-like 3 (INSL3) is a peptide hormone important for regulating male reproductive physiology. INSL3 belongs to the insulin/relaxin family of...
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Five core themes of intentional team formation
Cohesive group dynamics and innovative scientific ideas are essential components of successful research collaborations. However, the group dynamics...
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Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach
Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains,...
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Paediatric proteomic signatures of cardiometabolic disease-associated traits predict adult disease outcomes
While the earliest pathological signs of cardiovascular–kidney–metabolic disease (CKMD) emerge before age 20, current adult-based risk thresholds...
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Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease
Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer’s disease (AD) and is particularly pronounced in individuals carrying the APOE...
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Explainable Binary Classification of Separable Shape Ensembles
Scientists, engineers, biologists, and technology specialists universally leverage image segmentation to extract shape ensembles containing many...
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Region-specific forest structure pathways reveal climate effects on old-growth tropical forest biomass
Old-growth tropical forests store vast amounts of carbon in their aboveground biomass (AGB), yet the relative roles of abiotic factors such as...
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Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes
Eating disorders—including anorexia nervosa (AN), bulimia nervosa and binge-eating disorder—are clinically distinct but exhibit symptom overlap and...
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Inflammatory neuropathy in mouse and primate models of colorectal cancer
Colorectal cancer survivors are at increased risk of developing neurological issues, particularly peripheral neuropathy and chronic pain. Although...
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α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson’s disease
The primary mechanism and subcellular localisation of α-synuclein toxicity in Parkinson’s disease pathogenesis remain unknown. We spatially and...
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FNIP1 variants are associated with favourable metabolism in 1 million humans
Altered energy metabolism is a shared driver across cardiometabolic diseases—the leading cause of death globally
1 . Energy metabolism varies between...
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Integrated care pathway in individuals with Long COVID: STIMULATE-ICP, a cluster-randomized, phase 3 trial
Combining multidisciplinary care plans into integrated care pathways (ICPs) is scalable, generalizable and effective for several long-term...
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Adaptive policies balancing trade, productivity and cropland increases can support Zambia’s nutrition security under future climate shocks
Policies in sub-Saharan Africa are constrained by a limited knowledge of climate change extremes and a focus on agricultural production rather than...
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Composition, diversity, and local use of plants in traditional agro-ecosystems and their link to the sustainable development goals (SDGs) in the North Pare Mountains, Tanzania
Mountain agricultural landscapes represent mosaics of land use and cover that often support high species diversity and ecosystem services. In...
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Mapping drivers of life expectancy change in Asia from 1990 to 2023
Life expectancy is a key indicator of population health and an important guide for health policy
1 ,2 . Although Asia represents approximately 60% of...
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Child health-related behaviors, social connectedness, and impact of the COVID-19 pandemic on children born preterm in the ECHO Cohort
BackgroundWe evaluated the impact of the COVID-19 pandemic on adolescents born preterm versus at term.
MethodsThis prospective cohort study included...
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Evaluating the impact of frailty in older adults on functional outcomes post-mechanical thrombectomy: a multicentre study incorporating traditional and machine learning methods
Frailty is associated with high risk of mortality. Our study evaluated frailty as a predictor of outcomes in older adults with acute ischemic stroke...
