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Anticoagulation for venous thromboembolism in adults with advanced kidney disease: UK Kidney Association clinical practice guideline
Patients with chronic kidney disease (CKD) have an increased risk of developing venous thromboembolism (VTE), with the risk increasing as kidney...
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Addressing evidence gaps in haemodialysis care: a critical review of clinical trials, technological innovations, and implementation priorities
Kidney failure treated with maintenance haemodialysis (HD) carries high risks of premature mortality, hospitalisation and impaired quality of life,...
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A compendium of next-generation patient-derived models for diverse cancers
The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models
1 ,2 . However,...
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Regional juxtacortical microstructural changes and gene expression provide insights into neurodegeneration in Alzheimer’s disease
White matter microstructural changes play a crucial role in cognitive decline in aging and neurodegenerative disorders including Alzheimer’s disease...
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A digitally controlled silicon quantum processing unit
Commercially relevant quantum computers will require large numbers of high-performing qubits that can be manufactured, integrated and controlled at...
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Immune correlates of risk for SARS-CoV-2 infection in children: a prospective, community-based cohort study
Few studies have characterized immune correlates of SARS-CoV-2 infection risk in children, particularly those with hybrid immunity from vaccination...
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Oxytocin and RAGE signaling at the intersection of social neurodevelopment and inflammation
BackgroundAutism spectrum disorder (ASD) prevalence continues to rise despite no recent changes to screening or diagnostic criteria. A complete...
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A 98-qubit trapped-ion quantum computer with all-to-all connectivity
Quantum computers require both high-fidelity operations and large qubit numbers to surpass classical capabilities
1 . Trapped-ion platforms have...
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A computational model to describe multi-regional brain architecture during neurodegeneration in Alzheimer’s disease
We previously proposed an MRI-based machine learning model to describe the mesoscopic architecture of the human brain to aid in classifying subjects...
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Food Insecurity and Cognitive Performance Among Young People Living With and Without HIV: A Study Across Four African Countries
Cognitive development in young adulthood among people living with HIV (PLWH) is not well understood, especially in the context of food insecurity...
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Consensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias
To better characterize the genetic architecture underlying Alzheimer’s disease (AD) and related dementias (ADRD), we performed a meta-analysis of...
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Critical habitats for sharks and rays in Asia remain largely unprotected
The Asia region harbors exceptional chondrichthyan (shark, ray, and chimaera) diversity but faces intense fishing pressure. The Important Shark and...
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Co-occurring clonal hematopoiesis exhibits strong selection and high leukemia risk
Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) are two types of clonal hematopoiesis (CH)...
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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegeneration
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves...
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Social and demographic predictors of willingness to participate in an exception from informed consent trial
BackgroundCommunity consultation and public disclosure are key components of exception from informed consent (EFIC) trials, and mandated by the US...
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Genetic modifiers of APOE-ε4-associated cognitive decline
The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease. However, APOE-ε4 is not deterministic, highlighting the...
