Search
Search Results
-
COVID-19 vaccination induces cross-neutralisation of sarbecoviruses related to SARS-CoV-2
The combined threats of future sarbecovirus zoonosis and continually emerging SARS-CoV-2 VOCs highlight the need to assess the breadth of existing...
-
Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals
The clinical and biological heterogeneity of major depressive disorder (MDD) may reflect the aggregation of different conditions with distinct...
-
Probing the limits of genetic recoding using multi-omics-guided evolution
Engineering the genetic code—by reassigning multiple of the 64 natural codons—enables making organisms resistant to all viruses, preventing genetic...
-
Vertex-wise cortical abnormalities in major depressive disorder from 64 cohorts from the DIRECT and ENIGMA MDD consortia
Major depressive disorder (MDD) is common and disabling, yet reported brain structural differences vary across studies. Here we performed a large...
-
Neurological and respiratory outcomes of the HIPTox controlled double-blind air pollution exposure trial
Air pollution, particularly particulate matter (PM), is a well-established risk factor for cardiopulmonary disease, but its impact on brain health...
-
Obesity rise plateaus in developed nations and accelerates in developing nations
Global reporting of obesity is commonly based on comparisons over multiple decades
1 and lacks a granular and systematic analysis of its dynamics. We...
-
Developing a core outcome set for the NeuroPoint Alliance Quality Outcomes Database Pediatric Tumor Surgery Registry: a modified Delphi study
PurposeProspective, multi-institutional surgical data collection in pediatric neuro-oncology remains limited despite substantial variation in...
-
Correlated insulator in the kagome flat band of a two-dimensional electrostatic crystal
The electronic properties of solids are determined by their crystal structure and electron interactions, giving rise to phenomena such as...
-
The effect of delays in cancer surgery due to the COVID-19 pandemic on cancer resectability and postoperative mortality in different tumor entities
BackgroundDuring the COVID-19 pandemic, prioritization of COVID-19 patients led to delays in oncological surgery, potentially impacting patient...
-
Predicting trajectories of illness using RNA velocity of whole blood
Transcriptomic analyses reveal the status of cells, tissues, or organisms, across states of health and disease. RNA velocity adds a temporal...
-
Clinical spectrum of intraocular inflammation following faricimab intravitreal injections: evidence from a large real-life cohort in the United Kingdom
ObjectiveTo describe the clinical findings and report the incidence of patients developing non-infectious intraocular inflammation (IOI) following...
-
TaIlored ManagEment of Sleep (TIMES) for people with dementia and mild cognitive impairment in primary care in England: protocol for a feasibility cluster-randomised controlled trial
BackgroundPeople living with dementia (PLWD) and mild cognitive impairment (MCI), and their family carers, often experience sleep disturbance which...
-
Genomic risk model to implement precision prostate cancer screening in clinical care: the ProGRESS study
Precision healthcare aims to tailor disease prevention and early detection to individual risk. Prostate cancer screening may benefit from...
-
Ageing promotes microglial accumulation of slow-degrading synaptic proteins
Neurodegenerative diseases affect 1 in 12 people globally and remain incurable. Central to their pathogenesis is a loss of neuronal protein...
-
Hygrothermal Effects on FRP and Vinyl Ester: Saline Exposure
This study investigates the hygrothermal effects of saline environments on Fiber Reinforced Polymers (FRPs), focusing on the moisture absorption,...
-
Factors associated with adverse haemodynamic events during the STARRT-AKI trial: a post-hoc secondary analysis
IntroductionHaemodynamic adverse events related to renal replacement therapy are a complication of all RRT modalities used in the ICU, including...
-
Cost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis
BackgroundProcalcitonin (PCT)-guided antibiotic duration for critically ill adults with sepsis may be clinically effective and safe. However,...
-
Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma
Driver mutations in IDH1 and IDH2are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence...
-
Multi-omics analysis of a pig-to-human decedent kidney xenotransplant
Organ shortage remains a major challenge in transplantation, and gene-edited pig organs offer a promising solution
1 –3 . Despite gene editing, the...
