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A 98-qubit trapped-ion quantum computer with all-to-all connectivity
Quantum computers require both high-fidelity operations and large qubit numbers to surpass classical capabilities
1 . Trapped-ion platforms have...
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Genome-wide association study of copy number variations in Parkinson’s disease
We investigated the role of copy number variations (CNVs) in Parkinson’s disease (PD) using genotyping data from 10,815 patients (2731 early-onset...
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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegeneration
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves...
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Reconstruction of the lifeways of Central European Late Bronze Age communities using ancient DNA, isotope and osteoarchaeological analyses
The Late Bronze Age (ca. 1300–800 BCE) of Central Europe is often characterised as a period of increasing mobility, socioeconomic transformation,...
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Sex and APOE genotype specific brain regional vulnerability to Alzheimer's Disease
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex...
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Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion
Systematically designing regulatory elements for precise gene expression control remains a central challenge in genomics and synthetic biology. Here...
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Spike-wave discharges are uncoupled with cognitive outcome in aged Long-Evans rats
RationalRodent EEGs display 7–12 Hz oscillations called spike-wave discharges (SWDs) that are more abundant with age, and some data suggest that they...
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Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health
Delay discounting (DD), a person’s preference for smaller immediate rewards over larger delayed rewards, is a heritable trait that is associated with...
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Universal consensus 3D segmentation of cells from 2D segmented stacks
Cell segmentation is the foundation of a wide range of microscopy-based biological studies. Deep learning has revolutionized two-dimensional (2D)...
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Brain-wide representations of prior information in mouse decision-making
The neural representations of prior information about the state of the world are poorly understood
1 . Here, to investigate them, we examined...
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Association between polygenic risk and survival in breast cancer patients
BackgroundPolygenic risk scores (PRS) estimate an individual’s germline genetic predisposition to a quantitative trait and/or risk of disease....
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The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
The Greatwall kinase inhibits PP2A-B55 phosphatase activity during mitosis to stabilise critical Cdk1-driven mitotic phosphorylation. Although...
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Left ventricular global longitudinal strain and diagnostic yield of genetic testing in hypertrophic cardiomyopathy in a multicenter registry analysis
In this multicenter study we investigated whether echocardiography-derived left ventricular global longitudinal strain (LV GLS), an indicator of...
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Institutional status and support for campus-community partnerships in Austrian higher education: exploring faculty perceptions of implementation and challenges
Amidst growing expectations for higher education institutions (HEIs) to address societal challenges through multi-perspective educational and...
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The phenomenology of psilocybin’s experience mediates subsequent persistent psychological effects independently of sex, previous experience, or setting
BackgroundRecent studies intensively explore psilocybin’s antidepressant potential, but variables like previous experience, repeated use, setting,...
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Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learning
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution...
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Flatback Deformity from Lumbosacral Tumor Surgery
Flatback deformity is the complication of lumbar and lumbosacral fusions characterized by loss of lumbar lordosis with a resultant forward...
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De novo Spondylolisthesis from Pathological Posterior Element Disruption
Spondylolisthesis is a description of the translation of one vertebra over another. Though most commonly seen in the degenerative setting, oncologic...
