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Food Effect on the Pharmacokinetics of VC004, a Tropomyosin Receptor Kinase Inhibitor: A Randomized Crossover Trial in Healthy Chinese Subjects
Background and ObjectiveVC004 is a novel next-generation tropomyosin receptor kinase (TRK) inhibitor that is approved for the treatment of advanced...
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Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors
BackgroundClinical trials have reported the efficacy of tropomyosin receptor kinase (TRK) inhibitors against neurotrophic receptor tyrosine kinase...
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A novel variant in the tropomyosin 3 gene presenting as an adult-onset distal myopathy - a case report
BackgroundWe report a patient with a novel c.737 C > T variant (p.Ser246Leu) of the TPM3 gene presenting with adult-onset distal myopathy.
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Differential immunoreactivity of alpha-smooth muscle actin in the mouse colon
Regional differences between left and right sides of the colon are well documented, but variation in smooth muscle cell differentiation remains...
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Neurotrophin mimetics and tropomyosin kinase receptors: a futuristic pharmacological tool for Parkinson’s
Parkinson’s disease is a complex age-related progressive dopaminergic neurodegenerative disease consistently viewed as a disorder of movement and is...
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Forensic applications of postmortem protein analysis in estimating the time since death: a systematic review
Estimating the postmortem interval (PMI) represents one of the most complex challenges in forensic medicine, especially beyond the first hours after...
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Surgical resection and targeted therapy in a pediatric NTRK-rearranged low-grade spindle cell sarcoma: a case report
BackgroundNeurotrophic tropomyosin receptor kinase (NTRK) gene fusions have emerged as important oncogenic drivers across a wide range of...
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Postmortem interval estimation through skeletal muscle protein degradation: a comprehensive review
Postmortem interval (PMI) estimation is a pivotal challenge in forensic science, and skeletal muscle protein degradation has emerged as a promising...
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Shrimp Extract Exacerbates Allergic Immune Responses in Mice: Implications on Clinical Diagnosis of Shellfish Allergy
Tropomyosin has been identified as the major cross-reactive shellfish allergen, but recent studies showed the presence of other clinically relevant...
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Advances in Shellfish Allergy Therapy: From Current Approaches to Future Strategies
Shellfish allergy, triggered by immune reactions to crustacean and mollusk proteins upon consumption/inhalation, is one of the most severe and...
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A TPM2 mutation causes congenital myopathy with fibre-type disproportion
We report a 9-year-old girl with delayed motor milestones and respiratory difficulty since birth. She presented as a floppy infant, with generalised...
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Single-cell transcriptomics of pediatric Burkitt lymphoma reveals intra-tumor heterogeneity and markers of therapy resistance
Burkitt lymphoma (BL) is the most frequent B-cell lymphoma in pediatric patients. While most patients are cured, a fraction of them are resistant to...
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Toward in vivo proof of binding of 18F-labeled inhibitor [18F]TRACK to peripheral tropomyosin receptor kinases
BackgroundTropomyosin receptor kinases (TrkA, TrkB, TrkC) are a family of tyrosine kinases primarily expressed in neuronal cells of the brain....
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Hypertrophic cardiomyopathy: insights into pathophysiology and novel therapeutic strategies from clinical studies
BackgroundHypertrophic cardiomyopathy (HCM) is a frequently encountered cardiac condition worldwide, often inherited, and characterized by intricate...
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TPI1 and TPM4 are strong candidate RNA biomarkers for systemic sclerosis
BackgroundSystemic Sclerosis (SSc) is an autoimmune rheumatic disease (ARD) with unclear aetiopathogenesis. Disease prognosis, diagnosis, and...
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Antibody-dependent cellular phagocytosis of tropomyosin receptor kinase C (TrkC) expressing cancer cells for targeted immunotherapy
Conventional cancer therapies such as chemotherapy are non-selective and induce immune system anergy, which lead to serious side effects and tumor...
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Identification of a rare variant in TNNT3 responsible for familial dilated cardiomyopathy through whole-exome sequencing and in silico analysis
BackgroundDilated cardiomyopathy (DCM) is a prevalent etiology of heart failure, distinguished by the gradual and frequently irreversible myocardial...
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Investigative assessment of the neuro-modulatory potentials of cannabichromene in TrkB/BDNF-mediated neurosignaling pathway
Cannabichromene (CBC) is the third most abundant non-psychoactive cannabinoid found in Cannabis sativa. It is reported to be responsible for...
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BDNF–TrkB signalling: a neurotrophic pathway to cardiovascular protection
The brain-derived neurotrophic factor (BDNF)–tropomyosin receptor kinase B (TrkB) signaling axis has emerged as a promising frontier in...
