Latest research

  1. Article

    Hypersensitivity reactions to pertuzumab/trastuzumab fixed-dose combination (PHESGO®): successful management with a simplified 9-step subcutaneous desensitization protocol

    • Mattia Cristallo
    • Mirco Filieri
    • Attilio Di Girolamo

    Hypersensitivity reactions (HSRs) to anti-HER2 monoclonal antibodies may limit access to optimal therapy in HER2-positive breast cancer. HSRs have been reported with both intravenous pertuzumab/trastuzumab and the fixed-dose subcutaneous...

    30 September 2026
  2. Article

    Ultra-low-dose induction phase in oral immunotherapy for children with severe peanut and walnut allergies: a multicenter observational cohort study

    • Kyoko Nishikage
    • Yuichiro Imai
    • Satoru Shinoda

    Background Peanut and tree nut allergies are increasing worldwide and have become a major cause of anaphylaxis in Japan. Although oral immunotherapy (OIT) is a promising treatment, conventional OIT cannot be initiated in patients with an extremely...

    28 September 2026 Open access
  3. Article

    Intraoperative protamine-induced anaphylaxis suggesting the possible involvement of an immunoglobulin E-dependent pathway based on basophil activation tests: a case report

    • Masaki Orihara
    • Tomonori Takazawa
    • Shigeru Saito

    Background Protamine is a recognized cause of perioperative anaphylaxis; however, its underlying mechanism remains incompletely understood. We report a case of protamine-induced anaphylaxis, in which skin testing and basophil activation tests (BATs)...

    26 September 2026 Open access
  4. Article

    Association of self-reported asthma symptoms and allergic rhinoconjunctivitis with truck traffic frequency and environmental tobacco smoke exposure among preschool children in Gauteng townships, South Africa

    • Mandla Bhuda
    • Janine Wichmann
    • Joyce Shirinde

    Background This study aimed to investigate the association between self-reported asthma symptoms, allergic rhinoconjunctivitis, truck traffic frequency, and environmental tobacco smoke exposure among preschool children in Gauteng townships, South...

    25 September 2026 Open access
  5. Article

    Food allergen sensitization on a standardized specific-IgE core panel in the West Bank, Palestine: a retrospective analysis of 1,339 Patients, 2016–2026

    • Ibrahim Salhi
    • Ansam Mazraawi
    • Ibrahim Salhi

    Local data on food allergen sensitization in the West Bank of Palestine are scarce, and clinicians rely on allergen panels derived from dissimilar Western populations. We describe the sensitization profile of patients referred for specific-IgE...

    23 September 2026 Open access
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