Uncover the latest and most impactful research in Gene Expression. Explore pioneering discoveries, insightful ideas and new methods from leading researchers in the field.
The ANK3gene has been conclusively linked to bipolar disorder, but its role in disease etiology remains unclear: both the specific transcript and its expressing cell type remain unclear. This is a near-universal problem for genes associated with...
Background Sex-associated differences in hippocampal function are well-recognized, yet the molecular mechanisms underlying these variations remain incompletely understood. In the CA1 region, the spatial organization of the transcriptome between the...
Background Monovalent metal cations are crucial for the formation of DNA secondary structures G-quadruplexes (G4s), which are abundant in gene promoters. Various physiological and pathological conditions are associated with the Na+i/K+iratio...
Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive sarcoma characterized by the pathognomonic EWS::WT1 fusion protein (FP), an oncogenic chimeric transcription factor (OCTF) resulting from the t(11;22)(p13;q12) translocation. Recent...
Background Pressure therapy (PT) is a well-established clinical treatment for hypertrophic scars (HS). While its efficacy in reducing scar thickness and hardness is recognized, the specific molecular mechanisms and cellular targets underlying its...
Background Diabetic ulcers (DU) are a severe complication of diabetes mellitus and are associated with infection, recurrence, amputation, and excess mortality. Robust molecular markers that distinguish ulcer tissue from non-ulcer tissue and clarify...
Alternative polyadenylation (APA) has a central role in regulation of the fate of mRNA and exhibits high variability in the brain and in neurons. However, brain APA regulation has not been mapped at cell type resolution, and the genetic control of...
Pulmonary arterial hypertension (PAH) is characterized by a neurohumoral imbalance. We studied the effect of PAH on transcriptional activity in pulmonary artery preparations. In rats with PAH induced by monocrotaline (60 mg/kg), pulmonary artery...
The expression of the gene denominated foraging (for) has been associated with locomotor activity and foraging behavior in several insect species. In the mosquito Aedes aegypti, however, the expression patterns of for orthologue (Aafor) and its role...
Background We have previously demonstrated that the linear decrease in postmenopausal breast cancer incidence with increasing parity is linked to expression changes in hundreds of genes in the peripheral blood cells of healthy women. However, these...
Aquatic animals can perceive predator-derived chemical cues and induce defensive responses. However, the mechanisms by which sessile bivalves respond to such predator signals at the tissue level remain poorly understood. To address this gap, Crassostr...
Abstract Thermococcus onnurineus NA1 exhibits growth by oxidizing carbon monoxide (CO) or formate to generate hydrogen gas (H2). The EnfR protein has been identified as a crucial regulator of carboxydotrophic metabolism in this strain, controlling...
RNA-binding proteins (RBPs) are required for RNA maturation processes, including capping, splicing, polyadenylation, and export. However, our understanding of gene-specific sequential RBP recruitment for mRNP assembly has been limited. To...
Helicobacter pylori infection is a key environmental risk factor implicated in the pathogenesis and progression of gastric cancer. However, the molecular mechanisms linking H. pylori colonization to key tumor-related gene expression remain...
Genetic risk variants in bipolar disorder (BD) may lead to substantial gene expression changes. Transcriptomic studies employing multiplex BD families are extremely scarce. Here, we performed RNAseq on total mRNA of 31 lymphoblastoid cell lines from...
Troponin is classically recognized as the central regulator of striated muscle contraction. However, emerging evidence indicates that troponin subunits are also expressed in numerous non-muscle cell types, where they perform diverse non-classical...
Intertidal burrowing bivalves, such as razor clam Sinonovacula constricta, are economically significant aquaculture species in coastal China. However, they exhibit high susceptibility to heat stress under global warming, which poses a substantial...
Background Holstein cattle are selected for high milk yield but show limited adaptation to hypoxic environments. The transcriptional features underlying their long-term response to hypoxic stress, particularly the role of non-coding RNAs, remain...
CRISPR-based gene drive systems have emerged as promising strategies for mosquito population control to reduce the impact of vector-borne diseases such as malaria. However, their broader molecular impact on the mosquito transcriptome remains poorly...
The pathogenesis of major depressive disorder (MDD) remains insufficiently understood, which may be due to the limitations of bulk tissue analyses in addressing cellular heterogeneity. In this study, we applied a comprehensive approach combining...
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BMC Genomics is an open access, peer-reviewed journal that considers articles on all aspects of genetics, genomics, transcriptomics and proteomics. The...
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Genome Biologycovers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research, new...
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Oncogene aims to make substantial advances in our knowledge of processes that contribute to cancer by publishing outstanding research. Oncogene...
