Uncover the latest and most impactful research in Myelodysplastic syndrome. Explore pioneering discoveries, insightful ideas and new methods from leading researchers in the field.
Background Graves’ disease (GD) is a relatively common form of thyrotoxicosis. Neutropenia is occasionally observed in patients with GD at the time of diagnosis, and the presence of pre-existing neutropenia may influence the choice of treatment. The...
Acute myeloid leukemia (AML) is characterized by complex molecular alterations including mutations in epigenetic regulators such as IDH1 and DNMT3A, which are associated with globally altered DNA methylation affecting gene transcription, treatment...
Sickle cell disease (SCD) is a major public health challenge in Uganda, where up to 20% of the population in northern regions carry the sickle cell trait (SCT). We conducted a community-based cross-sectional study among 321 sexually active unmarried...
Background ZNF292alterations are recurrently detected in patients with chronic lymphocytic leukemia (CLL), occurring in 3%-6% of patients as mutations and in 2% as 6q deletions. Although preliminary evidence suggested an independent prognostic role...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the only curative therapy for myelodysplastic neoplasms/syndromes (MDS), but post-transplant relapse continues to limit long-term survival. Reliable identification of patients at...
Purpose Telomere length analysis (TLA) is used to identify telomere biology disorders (TBD) in aplastic anemia (AA); however, the diagnostic performance of quantitative PCR (qPCR)-based TLA across germline mutation categories remains poorly defined....
Objectives This study aimed to characterize the clinical and laboratory features associated with juvenile dermatomyositis-associated macrophage activation syndrome and to identify warning features that may facilitate recognition of concurrent MAS at...
Acute myeloid leukemia (AML) is a hematologic malignancy in which accurate subtype identification is important for treatment planning and prognosis. This study developed a deep learning approach for AML subtype classification using multiple...
Myelodysplastic syndromes (MDS) in young adults are uncommon and underrepresented in transplant cohorts. We evaluated 697 patients aged 18–40 years who underwent first allogeneic hematopoietic cell transplantation (allo-HCT) reported to the EBMT...
Clonal hematopoiesis of indeterminate potential is associated with systemic inflammation and increased malignant risk in humans, yet understanding of how it reshapes the bone marrow (BM) microenvironment has been limited. Using single-cell...
Background Clonal hematopoiesis (CH) increases with age; however, population-based Korean data defined using variant-level driver criteria remain limited. We characterized CH in a large community-based Korean whole-genome sequencing (WGS) cohort...
Background Cardiac amyloidosis is an infiltrative cardiomyopathy caused by extracellular deposition of insoluble amyloid fibrils. Despite the growing global recognition of cardiac amyloidosis and the recent development of targeted therapeutic...
Myelofibrosis is a clonal myeloproliferative neoplasm characterized by progressive remodeling of the bone marrow microenvironment. Megakaryocyte (MK) abnormalities are defining histological features of prefibrotic and overt primary myelofibrosis and...
Diagnosing leukaemia from microscopic blood smear images is nevertheless challenging for traditional Computer-Aided Diagnosis (CAD) systems. Many current methods depend on segmentation and basic feature representations. This makes it hard to tell...
Immunosuppressive therapy (IST) plus eltrombopag (EPAG) (IST+EPAG) is the preferred first-line treatment for severe aplastic anemia (SAA) patients over 40 years. However, direct comparison between IST+EPAG and upfront haploidentical hematopoietic...
The utility of whole-genome sequencing (WGS) for detecting childhood leukemia predisposition remains unclear. We perform a nationwide, prospective, population-based study of 181 children with acute leukemia to assess diagnostic yield and clinical...
Background Antithyroid drug-induced agranulocytosis (TIA) is a serious adverse effect in Graves’ disease treatment. This study aims to analyze neutrophil recovery patterns in TIA patients. Methods We conducted a 12-year retrospective study of...
