Uncover the latest and most impactful research in Signalling gradients. Explore pioneering discoveries, insightful ideas and new methods from leading researchers in the field.
Approximately 10% of US births deliver preterm before 37 weeks of completed gestation. Premature infants are at risk for life-long debilitating morbidities and death, and spontaneous preterm labor explains 50% of preterm births. There are currently...
An initial break in plasma membrane symmetry triggers hundreds of spatiotemporally controlled signaling and cytoskeletal events that regulate cell polarization during migration and macropinocytosis. However, the mechanism driving this...
Hydraulic gradients (HGs) at the land–water interface display intrinsic dynamism, with their magnitude and variability serving an essential function in determining the behaviour of contaminants such as light non-aqueous phase liquids (LNAPLs)....
In developing tissues, signal transduction from morphogen gradients conveys positional information to cells, resulting in cell specification and differentiation. One such morphogen is bone morphogenetic protein (BMP), a highly conserved member of...
Urban traffic networks exhibit strong asymmetry in flow distribution, where delays on dominant movements—such as arterial corridors—can trigger disproportionate network-level degradation through congestion propagation and spillback. While many...
The tumour microenvironment comprises a variety of cell types that interact with malignant cells, influencing both cancer progression and the patient response to therapy. Given the intricate interactions among these components, assessing how...
Submesoscale sea surface temperature (SST) variability can modulate near-surface winds through the downward momentum mixing mechanism, whose strength depends on the intensity and orientation of SST gradients relative to the wind. In regional climate...
A fundamental challenge in regional landslide early warning is that conventional systems apply uniform rainfall thresholds without accounting for the distinct triggering responses of different landslide types. Even when multiple type-specific...
Mixed-autonomy urban networks may experience rapid service degradation when local capacity losses interact with demand surges and queue spillback. This study formulates disturbance-period traffic management as a service-maintenance problem and...
While gene regulatory networks (GRNs) are fundamental to understanding complex cellular mechanisms, the accurate inference from single-cell RNA-sequencing (scRNA-seq) data is hindered by the inherent noise, transcriptional dropout events, and...
In multi-traffic signal control, the overarching objective is to optimize regional traffic metrics such as average queue length and travel time. Conventional approaches rely on credit assignment within multi-agent reinforcement learning (MARL) to...
Over the last decades, there has been growing interest in the characterization of ionospheric total electron content (TEC) for the effective planning, implementation and optimum performance of the satellite-based technology applications. This paper...
Background Percutaneous intramyocardial septal radiofrequency ablation is an emerging septal reduction strategy for obstructive hypertrophic cardiomyopathy, but comparative routine-care data remain limited. We evaluated early hemodynamic response,...
Overcoming the strength-ductility trade-off remains a critical challenge for advanced structural materials. Metal matrix composites (MMCs) featuring spatially tailored gradient architectures and engineered interfaces offer a transformative solution....
Model watermarking supports intellectual-property claims by verifying a model’s responses to a secret key set, but this behavior-only interface is vulnerable to fabricated evidence. This work presents FakeMark, a gradient-guided false-claim attack...
Reinforcement learning-based traffic signal control (RL-TSC) has emerged as a promising approach for improving urban mobility. However, its robustness under real-world disruptions such as traffic incidents remains largely underexplored. In this...
Extracellular vesicle (EV) transcriptomes are widely used to build competing endogenous RNA (ceRNA) networks. In these networks one RNA is thought to relieve another from microRNA repression by competing for the same microRNAs. They rest on one...
Manipulating the signaling environment is an effective approach to alter cellular states for broad-ranging applications. Such manipulation requires knowing the signaling states and histories experienced by cells in vivo, for which high-throughput...
The attraction–repulsion chemotaxis system $$\begin{aligned} \left\{ \begin{array}{l} \begin{aligned} & u_t=\Delta u-\nabla \cdot (u|\nabla v|^{p-2}\nabla v)+\nabla \cdot (u|\nabla w|^{p-2}\nabla w), & x\in \Omega ,\ t>0& ,\\ & 0=\Delta v-v+u, &...
The Ta/Al/Ta laminated composite was fabricated by hot press sintering using an Al powder interlayer for aerospace radiation shielding. A gradient substructure with finer grains near the interface developed in the Ta layer. Increasing holding time...
