Acta Pharmacologica Sinica

Structure genomics of SARS-CoV-2 and its Omicron variant

Status epilepticus-induced 12/15-lipoxygenase drives neuroinflammation and contributes to neuronal injuries and behavioral comorbidities

Md. Asaduzzaman Rakib
Eun Bee Cho
Jianxiong Jiang

Article 13 February 2026

Featured

Zinc finger BED-type containing 6 (ZBED6) ameliorates cardiac fibrosis by inhibiting Piezo1 transcription and YAP nuclear translocation

Han Wu
Wei-tao Jiang
Yu Bian
ArticleOpen Access19 Jan 2026
ER-phagy receptors: structural mechanisms in selective ER degradation and disease implications

Wen-jing Yang
Rui Sheng
Review Article27 Jan 2026
Cannabidiol inhibits both human K_V7.1 and K_V7.1/KCNE1 channels through distinct sites

AS Kusay
M. Pökl
SI Liin
ArticleOpen Access03 Mar 2026
AI and experimental convergence: a synergistic pathway to JAK2 inhibitor discovery

Maryam
Hwangeui Cho
Hilal Tayara
ArticleOpen Access27 Jan 2026

Current issue

Modulation of metabolic, inflammatory, fibrotic, and cell death pathways by resmetirom in metabolic dysfunction-associated steatohepatitis (MASH): a transcriptomic profiling study

Chen-yang He
Zhi-hua Wang
Suo-wen Xu
Correspondence19 Feb 2026
GluD1 at the synaptic crossroads: from domain structure to circuit dysfunction

Poojashree B. Chettiar
Shashank M. Dravid
Review ArticleOpen Access04 Dec 2025
Roles and related underlying mechanisms of mitochondrial RNA modification in cancer progression

Ling-zhi Wang
Tao-yu Yang
Jun-ming He
Review Article01 Dec 2025
Serotonin receptor 4 in the ventral CA3 regulates agomelatine-induced anxiolytic-like behaviors

Xiang-hu Liu
Muhammad Naveed
Jing Zhang
Article01 Dec 2025
Adapter protein 2-modulated \({{{\rm{\mu }}}}\)-opioid receptor trafficking in paraventricular thalamus contributes to fentanyl contextual addiction memory in mice

Yu-jie Li
Ruo-song Chen
Zhi-qiang Liu
Article01 Dec 2025
Modest improvement of metabolic and behavioral deficits with long-term ambroxol treatment in a Pink1^−/−SNCA^A53T double mutant mouse model of Parkinson’s disease

Luisa Franck
Lucie Valek
Irmgard Tegeder
ArticleOpen Access08 Dec 2025

Volume 47 Issue 4

Contents

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Announcements

Editorial Excellence

Acta Pharmacologica Sinica, among the top 25% qualifying journals, is recognized for its exceptional editorial excellence, based on data collected from the 2024 Journal Author Satisfaction survey. Congratulations to the Acta Pharmacologica Sinica editors!

Browse articles

A novel CDK8/19 inhibitor RO8323 mitigates allograft rejection through dual mechanisms of action to modulate regulatory T cell and myeloid cell

Fang Shen
Rou Xie
Lue Dai
Article31 Mar 2026
Piroctone olamine promotes BECN1 transcription and activates autophagy by targeting HDAC6 in colorectal cancer

Cui-yun Cui
Qiu-tong Li
Yong-ping Jian
Article30 Mar 2026
Transcutaneous allicin oleogel restores energy homeostasis for obesity treatment

Quan-gang Xu
Ze-yun Gu
Yong-zhuo Huang
Article30 Mar 2026
Non-telomeric function deficiency of TERT enhances pressure overload-induced mouse cardiac remodeling by activation of CNBP-mediated THBS3/ITGB1 pathway

Ying-ying Liu
Ying-chao Wang
Qi-bin Jiao
Article25 Mar 2026
BMAL1 silencing as a promising chemosensitizing strategy for triple-negative breast cancer

Lu-yi Wang
Xue-han Xu
Qin Zhou
Article24 Mar 2026
MCOLN1-mediated PPP3CB activation alleviates neuronal damage by promoting TFEB-dependent autophagic flux in permanent cerebral ischemia

Shi-qi Liu
Yue-yang Liu
Jing-yu Yang
Article24 Mar 2026
Pathophysiological roles of neural stem cells in neuropsychiatric diseases: from plasticity to pharmacological targeting

Yun-yun Li
Xin-yu Wang
Wen-lu Li
Review Article23 Mar 2026
Microglial NLRP3-dependent pyroptosis promotes cognitive dysfunction of diabetic encephalopathy by inhibiting adult hippocampal neurogenesis through the release of IL-1β

Meng-yu Hua
Shan Huang
Shi-hong Chen
ArticleOpen Access20 Mar 2026
TNF-α/PAD4 axis drives hyperhomocysteine-induced white matter injury after acute ischemic stroke

Wei-hong Du
Hui Guo
Xin-chun Jin
Article20 Mar 2026

Collections

Image alternative text

Artificial Intelligence for Ion Channel Drug Discovery

In this collection, we present a selection of artificial intelligence (AI)-driven breakthroughs in ion channel drug discovery, featuring studies recognized in the 2023 Shanghai International Computational Biology Challenge—“Lingyue” Challenge of AI Algorithms for Drug Screening. We hope these works will offer unique insights into AI-enabled ion channel research and inspire future innovation.

Collection 25 Dec 2025

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Institute of Physics (IOP), Chinese Academy of Sciences (CAS)
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