Cell Death Discovery

Welcome to Cell Death Discovery

An international online only, open access journal dedicated to publishing scientifically sound research at the intersection of cell death and medicine.

Featured

Mitophagy in pancreatic cancer: mechanistic insights and implications for novel therapeutic strategies

Zhefang Wang
Zicheng Lyu
Yue Zhao
Review ArticleOpen Access05 Feb 2026
Activating GCN2 and subsequently the Unfolded Protein Response with the small oral molecule NXP800 delays tumor growth in osteosarcoma

Emma Racineau
Morgane Lallier
François Lamoureux
ArticleOpen Access05 Feb 2026
SUMOylation is destined for regulatory T cell-related immune dysregulation

Jinxiu Qian
Liuchunyang Yu
Yuanyan Liu
Review ArticleOpen Access03 Feb 2026
Mesenchymal stem cells alleviate experimental cerebral malaria disease severity by inducing RoRγt⁺ Foxp3⁺ T regulatory (Tr 17) cells and modulating the dysregulated Th17/Treg axis

Indu Sharma
Reva Sharan Thakur
Jyoti Das
ArticleOpen Access30 Jan 2026

Announcements

Precision Medicine Conference

You are invited to join our upcoming conference on 'Precision Medicine' taking place in April 2026. Location: Suzhou, China - Date: 23-24 April 2026 - Format: In-Person & Online More details in the link.
Letter to the Editor: Co-culture shock

Read the latest Letter to the Editor and response here
Celebrating 10 years of Cell Death Discovery

A decade ago research into the fundamental mechanisms of cell death: apoptosis, necroptosis, pyroptosis, ferroptosis, and emerging forms of programmed cell survival was rapidly expanding. To support rapid interdisciplinary publishing Cell Death Discovery was launched in 2015 as a sister journal to Cell Death & Differentiation and Cell Death & Disease. Read the editorial celebrating this landmark.

Browse articles

Mechanistic insights into SOCS5-related DNA damage and cellular senescence in diabetic retinopathy

Di Yang
Siduo Lu
Hua Zhong
ArticleOpen Access01 Apr 2026
Brain metastases exhibit distinct spatial patterns of resident and infiltrating macrophages

Avinoam Ratzabi
Itai M. Caspit
Reuven Stein
ArticleOpen Access01 Apr 2026
A unified therapeutic theory for treating cancer via master regulators of the universal apoptosis network

Davis Joseph
Florian Kongoli
Haruhiko Inufusa
Review ArticleOpen Access01 Apr 2026
O-GlcNAcylation of UGDH: emerging insights into immunometabolic regulation and therapeutic implications

Qiang Wu
Ting Lei
Shujing Wang
CommentOpen Access31 Mar 2026
Doxorubicin promotes the production of inflammatory cytokines in tumor-associated macrophages through activating lactate dehydrogenase A

Bin Liu
Wei Yang
Ting Sun
ArticleOpen Access31 Mar 2026
SNHG10 promotes tumorigenesis through the EGFR/AKT/ERK/mTOR and miR-150-5p/VEGF-A axis, along with gemcitabine resistance in pancreatic ductal adenocarcinoma

Gouri Pandya
Aishwarya Singh
Manoj Garg
ArticleOpen Access31 Mar 2026
Humic substances enhance the anti-cancer efficacy of standard therapies

Paola Bianca
Chiara Modica
Giorgio Stassi
ArticleOpen Access31 Mar 2026
Store-operated calcium entry drives alcohol-exacerbated neuroinflammation in retinal degeneration

Théo Henrique de Lima-Vasconcellos
Bruna de Albuquerque Menezes
Alexandre Hiroaki Kihara
ArticleOpen Access31 Mar 2026
Protein lactylation: a metabolic signal driving cancer therapy resistance

Silvia D’amico
Sara Giovannini
Francesca Bernassola
Review ArticleOpen Access31 Mar 2026

This Collection features our best recent content from CDDpress, which publishes forefront, innovative and international research covering the cell biology, molecular biology, and biochemistry of cell death and disease. Updated each month, this collection of articles includes content from all three CDDpress titles: Cell Death and Differentiation, Cell Death & Disease, and Cell Death Discovery.

Collection 14 Jan 2026

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Variant-divergent death: Omicron intensifies bystander T-cell apoptosis via GDF15–BCL2L13

AhR-dependent ferroptosis as a therapeutic opportunity to counteract BRAFi-resistance in melanoma

Protein phosphatase 2A methylation state impacts α-synucleinopathy in mouse models

Brain metastases exhibit distinct spatial patterns of resident and infiltrating macrophages

Science jobs

Associate or Senior Editor, Nature Communications (Computational Biology)

Title: Associate or Senior Editor, Nature Communications (Computational biology) Location: Shanghai, Beijing, New Delhi and Pune Application Deadl...

Shanghai, Beijing, New Delhi and Pune

Springer Nature Ltd

Global Recruitment for Faculty, Postdocs, and Specialists at Hangzhou Institute of Medicine, CAS

Seeking exceptional Senior/Junior PIs, Postdocs, and Core Specialists globally year-round

Hangzhou, China

Hangzhou Institute of Medicine Chinese Academy of Sciences (HIMCAS)

Seeking Excellent Young Scientists Fund (overseas) and academic positions at all levels

Seeking Excellent Young Scientists Fund (overseas), Full Professors, Associate Professors, Assistant Professors, Postdoctoral Associate.

Beijing (CN)

State Key Laboratory of Optoelectronic Materials and Devices at the Institute of Semiconductors, CAS

Faculty Positions at Institute of Physics (IOP), Chinese Academy of Sciences

IOP is China's premier research institution in condensed matter physics and related fields.

Beijing (CN)

Institute of Physics (IOP), Chinese Academy of Sciences (CAS)

Assistant Professor (Tenure Track) in Molecular Biology/Molecular Infection Medicine - Call for EOI

Expressions of interest are invited for an Assistant Professor role with a generous 5-year startup package of about SEK 20M (≈EUR 1.8M)

Umeå, Sweden

Umeå University

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Welcome to Cell Death Discovery

Featured

Mitophagy in pancreatic cancer: mechanistic insights and implications for novel therapeutic strategies

Activating GCN2 and subsequently the Unfolded Protein Response with the small oral molecule NXP800 delays tumor growth in osteosarcoma

SUMOylation is destined for regulatory T cell-related immune dysregulation

Mesenchymal stem cells alleviate experimental cerebral malaria disease severity by inducing RoRγt⁺ Foxp3⁺ T regulatory (Tr 17) cells and modulating the dysregulated Th17/Treg axis

Announcements

Precision Medicine Conference

Letter to the Editor: Co-culture shock

Celebrating 10 years of Cell Death Discovery

Browse articles

Mechanistic insights into SOCS5-related DNA damage and cellular senescence in diabetic retinopathy

Brain metastases exhibit distinct spatial patterns of resident and infiltrating macrophages

A unified therapeutic theory for treating cancer via master regulators of the universal apoptosis network

O-GlcNAcylation of UGDH: emerging insights into immunometabolic regulation and therapeutic implications

Doxorubicin promotes the production of inflammatory cytokines in tumor-associated macrophages through activating lactate dehydrogenase A

SNHG10 promotes tumorigenesis through the EGFR/AKT/ERK/mTOR and miR-150-5p/VEGF-A axis, along with gemcitabine resistance in pancreatic ductal adenocarcinoma

Humic substances enhance the anti-cancer efficacy of standard therapies

Store-operated calcium entry drives alcohol-exacerbated neuroinflammation in retinal degeneration

Protein lactylation: a metabolic signal driving cancer therapy resistance

Collections

CDDpress: Monthly Readers' Choice

Trending - Altmetric

Science jobs

Associate or Senior Editor, Nature Communications (Computational Biology)

Global Recruitment for Faculty, Postdocs, and Specialists at Hangzhou Institute of Medicine, CAS

Seeking Excellent Young Scientists Fund (overseas) and academic positions at all levels

Faculty Positions at Institute of Physics (IOP), Chinese Academy of Sciences

Assistant Professor (Tenure Track) in Molecular Biology/Molecular Infection Medicine - Call for EOI

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