ProTact, an SE(3)-invariant geometric GNN, enhances protein-protein contact prediction and docking by integrating physics-informed constraints. It surpasses existing methods in low MSA scenarios and enhances AlphaFold3’s confidence scores.

Modulating microbial intake helps to maintain the gut microbiome diversity as shown by mathematical modeling of intermittent migration to a community undergoing birth, death, and homogeneous competition in a biologically realistic regime.

The psychedelic substance psilocybin modifies the temporo-spatial aspects of global infraslow cortical activity across the serotonin receptor landscapes. These findings provide a link between macroscopic signatures of neuromodulatory activity, global brain events and receptor action, with relevance for understanding the mechanisms of psychedelic effects.

Simulated microgravity reveals species-specific effects on sperm navigation, fertilization, and early embryo development, highlighting compensatory mechanisms and chemical cues critical for reproduction in future space missions.

Cryo-EM analysis of fibrils from heart and liver of an ATTR amyloidosis patient with the V122Δ mutation reveals polymorphic single and double filaments, suggesting that fibril structural polymorphism may contribute to phenotypic variation in ATTR amyloidosis.

MIMIC is a reproducible workflow that integrates Mass Spectrometry Imaging and Imaging Mass Cytometry for joint downstream analysis, incorporating rigorous quality control and supporting pixel-level modeling to delineate analyte-cell type associations.

Cancer associated fibroblast subpopulations are identified by single cell and spatial sequencing as relevant components of the brain metastasis tumor microenvironment, where they participate in the tissue architecture and intercellular communication.

Single-nucleus transcriptomics sheds light on cellular pathways underlying sex differences in renal tubular response and repair during kidney infection.

Lisinopril is identified as a BI1 activator that counteracts ALS pathology. It remodels lipid metabolism, restores autophagic flux via TGFβ1/mTOR signaling, and mitigates fibrosis. This multi-target mechanism supports the therapeutic repurposing of lisinopril for ALS.

Antibacterial activity of Questiomycin A against Mycobacterium tuberculosis via direct targeting of FabD, effective against drug-sensitive and drug resistant strains.

Dr. Victor Borda is a Research Associate at the University of Maryland, School of Medicine, and the Institute for Health Computing. In this Q&A, we discuss his recent publication in Communications Biology on admixture and genetic diversity across Peru, his work with the Peruvian Genome Project, and the relevance of developing genomic resources in Latin America.

This comment delves into the need for statistically rigorous population estimation in cryo-electron microscopy. Examples are given illustrating the failure of particle counting and the robustness of principled techniques.

This Q&A explores the interdisciplinary advances in the EU Pathfinder project Microbial Hydroponics (Mi-Hy) and its SPIKA installation - a functional prototype installed at the Milan Triennale 2025. In this prototype, microbial electrochemistry, engineered biomineralization, and metabolic programming converge. Researchers Ezgi Öğün Ramalhete, Işıl Yücel, and Jorge Barriuso discuss how microbial consortia can reshape the foundations of the built environment by introducing a platform for sustainable agriculture. This might enable a transition from resource-consuming architecture to circular, living infrastructure.

A recent cavefish study overturns the classic view of photolyases as light-dependent enzymes. Research shows CPD photolyase repairs oxidative DNA damage in darkness, revealing a dual function that explains its conservation in cave species

Delta glutamate receptors are no longer considered silent scaffolds. This Comment discusses how GluD2 can be activated by structural asymmetry and temperature, emphasizing its potential role in synaptic plasticity.

Artificial intelligence is rapidly transforming structural biology and accelerating access to protein structures, yet many Africa-based scientists still lack infrastructure, training opportunities, and sustained mentorship to fully benefit. Here, we describe BioStruct-Africa’s community-driven framework integrating AlphaFold, experimental structural biology, and computational drug design to train 1000 scientists over the next decade.