npj Aging

The human pathome shows sex and tissue specific aging patterns

Michael Ben Ezra
Jonas Bach Garbrecht
Morten Scheibye-Knudsen

Article 30 January 2026

Featured

Similar minds age alike: an MRI similarity approach for predicting age-related cognitive decline

Blanca Zufiria-Gerbolés
Jiawei Sun
Joana B. Pereira
ArticleOpen Access06 Feb 2026
TNFα is a trigger of aging-associated liver inflammation in mice

Haktan Övül Bozkir
Annette Brandt
Ina Bergheim
ArticleOpen Access13 Jan 2026
Astaxanthin improves myogenicity of aged skeletal muscle progenitor cells in a sexually dimorphic manner

Zachary Clemens
Jagruti Kosaraju
Amrita Sahu
ArticleOpen Access10 Jan 2026
Reserpine prolongs lifespan but compromises locomotion and heat-stress resilience in Drosophila melanogaster

Vaibhav Tiwary
Nares Trakooljul
Shahaf Peleg
ArticleOpen Access12 Jan 2026

Announcements

Systems Aging - Gordon Research Conference

We are pleased to share that npj Aging will be supporting the 2026 Systems Aging GRC, which will be hosted at the Grand Summit Hotel at Sunday River in Maine, USA.
Our Calls for Papers

Check out our open collections here.
• Immuno-senescence.

• Public health and health governance in China.

• Mitochondria at the Heart of Aging: Structure, Function and Failure.

• Healthy eating and dietary intervention to promote longevity and prevent age-related diseases.

• Gerophysics.

• Sex differences in aging research.

Browse articles

Protein intake and its interaction with dietary patterns on clinical outcomes among older adults

Hélio José Coelho-Júnior
Emanuele Marzetti
ArticleOpen Access25 Mar 2026
Dietary metabolomic determinants of frailty through inflammation in the Canadian Longitudinal Study on Aging

Talha Rafiq
Jinhui Ma
Parminder Raina
ArticleOpen Access23 Mar 2026
Trajectories of physical function and biological aging in generally healthy older adults with and without incident invasive cancer over a three-year follow-up: findings from the DO-HEALTH study

Wiebke Rösler
Melanie Kistler-Fischbacher
Heike A. Bischoff-Ferrari
ArticleOpen Access23 Mar 2026
Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction

Michio Sato
Daishi Tanabu
Shigeru Yanagi
ArticleOpen Access20 Mar 2026
Electrocardiogram derived heart age models agreement, accuracy and predictive ability in the Tromsø study

Arya Panthalanickal Vijayakumar
Tom Wilsgaard
Olena Iakunchykova
ArticleOpen Access20 Mar 2026
The puzzling duality of mesenchymal stem cells and adipocytes in bone marrow and ageing

Blanca Gonzalez-Garcia
Cristina Aparicio
Sara M. Jaramillo-Carmona
PerspectiveOpen Access19 Mar 2026
Avoidance of rejuvenation: a stress test for evolutionary theories of aging

Samir I. Aisin
Boris V. Lidskii
Peter V. Lidsky
ArticleOpen Access18 Mar 2026
Hydroxychloroquine alleviates cyclophosphamide-induced premature ovarian failure by attenuating granulosa cell senescence and modulating the mtDNA-cGAS pathway

Dehui Su
Ruiqiong Ma
Xin Yang
ArticleOpen Access17 Mar 2026
Urbanization, environment, and inflammaging: insights from sub-Saharan Africa

Stephen W. Bickler
Matchecane Cossa
Emília V. Noormahomed
PerspectiveOpen Access13 Mar 2026

Collections

Mitochondria at the Heart of Aging: Structure, Function and Failure

This collection invites content on mitochondria in the context of aging --from mechanistic studies to disease models and tool development to relevant therapeutic modalities.

Collection 11 Jul 2025

Open for submissions

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Science jobs

Faculty Positions, Aging and Neurodegeneration, Westlake Laboratory of Life Sciences and Biomedicine

Applicants with expertise in aging and neurodegeneration and related areas are particularly encouraged to apply.

Hangzhou, Zhejiang, China

Westlake University School of Life Science
Research Scientist / Sr. Research Scientist or Postdoctoral Fellow

The DeKosky Laboratory at MIT and The Ragon Institute is hiring a computational researcher to advance computational drug design and discovery.

Cambridge, MA

DeKosky Laboratory at The Ragon Institute and MIT
Faculty Positions at SUSTech School of Medicine

SUSTech School of Medicine offers equal opportunities and welcome applicants from the world with all ethnic backgrounds.

Shenzhen, Guangdong, China

Southern University of Science and Technology, School of Medicine
Open Rank Faculty (All Levels) in Dept of Oncology Science

Open Rank Faculty (All Levels) in Dept of Oncology Science The newly established Department of Oncology Science, College of Medicine at the Unive...

Oklahoma City, Oklahoma

University of Oklahoma Health Campus
Faculty Positions for Female Researchers, Tohoku University

Eleven New Professor-Level Research Positions Opened for Female Candidates at Tohoku University

Japan (JP)

Tohoku University

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

The human pathome shows sex and tissue specific aging patterns

Featured

Similar minds age alike: an MRI similarity approach for predicting age-related cognitive decline

TNFα is a trigger of aging-associated liver inflammation in mice

Astaxanthin improves myogenicity of aged skeletal muscle progenitor cells in a sexually dimorphic manner

Reserpine prolongs lifespan but compromises locomotion and heat-stress resilience in Drosophila melanogaster

Announcements

Systems Aging - Gordon Research Conference

Our Calls for Papers

Browse articles

Protein intake and its interaction with dietary patterns on clinical outcomes among older adults

Dietary metabolomic determinants of frailty through inflammation in the Canadian Longitudinal Study on Aging

Trajectories of physical function and biological aging in generally healthy older adults with and without incident invasive cancer over a three-year follow-up: findings from the DO-HEALTH study

Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction

Electrocardiogram derived heart age models agreement, accuracy and predictive ability in the Tromsø study

The puzzling duality of mesenchymal stem cells and adipocytes in bone marrow and ageing

Avoidance of rejuvenation: a stress test for evolutionary theories of aging

Hydroxychloroquine alleviates cyclophosphamide-induced premature ovarian failure by attenuating granulosa cell senescence and modulating the mtDNA-cGAS pathway

Urbanization, environment, and inflammaging: insights from sub-Saharan Africa

Collections

Mitochondria at the Heart of Aging: Structure, Function and Failure

Trending - Altmetric

Science jobs

Faculty Positions, Aging and Neurodegeneration, Westlake Laboratory of Life Sciences and Biomedicine

Research Scientist / Sr. Research Scientist or Postdoctoral Fellow

Faculty Positions at SUSTech School of Medicine

Open Rank Faculty (All Levels) in Dept of Oncology Science

Faculty Positions for Female Researchers, Tohoku University

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Cost of care for Alzheimer’s disease and related dementias in the United States: 2016 to 2060

A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo

DeepStrataAge: an interpretable deep-learning clock that reveals stage- and sex-divergent DNA methylation aging dynamics

Avoidance of rejuvenation: a stress test for evolutionary theories of aging

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