China’s large, multi-generational pedigrees provide a distinctive genomic resource for precision medicine but present a governance challenge. We propose a new framework that addresses the core contradiction between individual-centric governance and the collective nature of these genomic datasets.

In this Journal Club, Emilie Brasset highlights a 1995 publication by Prud’homme et al., who designed a clever genetic assay to identify a gene important for TE silencing, which provided a crucial foundation for later studies to unravel the underlying mechanisms.

In this Journal Club, Yousuf A. Khan recounts a landmark study published in 1985 by Jacks and Varmus that documented programmed ribosomal frameshifting in retroviruses, which later inspired Yousuf to search for this phenomenon in vertebrates.

Chikashi Terao recalls a paper by Loh et al., which introduced a highly sensitive algorithm to detect low-fraction chromosomal mosaicism from SNP array data, enabling large-scale mapping of clonal haematopoiesis.

In this Tools of the Trade article, Jingchuan Luo discusses LOCL-TL (LOV domain-controlled ligase for translation localization), a method they helped develop to enable the study of subcellular translation at codon-level resolution.

In this Journal Club, Fumitaka Inoue discusses a 2009 paper by Patwardhan et al. that introduced a massively parallel saturation-mutagenesis assay that leverages high-throughput DNA synthesis and sequencing to quantify the effects of single-nucleotide changes on regulatory element activity.