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Could crystal methamphetamine have any physiological effect on this cholinergic synapse given the conditions below:

  1. No action potential reaches the presynaptic terminal.
  2. The extracellular Ca²⁺ concentration remains constantly high.
  3. The Ca²⁺ concentration inside the presynaptic terminal remains constantly low.
  4. The concentration of acetylcholine (ACh) in the synaptic cleft rises and then falls.
  5. A postsynaptic potential (PSP) is generated.
  6. The synapse is a chemical, cholinergic synapse that releases ACh.
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