Non-constructive counting proof that a counterexample exists. First for the original question, then for the follow-up. The basic idea is that if we consider a bound the elements of the set and increase it, the number of possible sets grows much much faster than the number of possible values for the sum and sum of squares.
First a simplification: We don't need to require the sets to be disjoint, only different. If we have two different sets $S$ and $S'$, then $S \setminus S'$ and $S' \setminus S$ are disjoint nonempty sets of equal size that have the same sum and sum of squares.
Let $S$ be a set of exactly $N$ natural numbers at most $M$.
The sum of $S$ is at most $NM$. The sum of squares of $S$ is at most $N M^2$. Therefore there are at most $(NM+1)(NM^2+1)$ pairs (sum, sum of squares).
There are $\binom{M+1}{N}$ different such sets.
Since $\binom{M+1}{4}$ is a 4th degree polynomial in $M$, it must be larger than $(4M+1)(4M^2+1)$ for large values of $M$. Therefore there exists an $M$ for which there are two different sets $S$ and $S'$ of size $4$ that have the same sum and sum of squares.
I don't see any counterexample, but assuming that there does exist one, can we add more similar polynomial identities, maybe qubes or something to prevent such counterexamples?
Similar approach works for all finite amounts of "polynomial identities".
To be exact, let's say you have $k$ polynomials $p_1, \ldots, p_k$ with integer values, and the question is whether there are two different sets of equal size such that $(\sum_{s \in S} p_1(s), \ldots, \sum_{s \in S} p_k(s))$ has the same value of those sets.
Let $l$ be the largest degree of the $p_i$'s. There exists a constant $C$ such that if $s \leq M$, then $|p_i(s)| \leq C M^l$.
So now, if $S$ has $N$ elements that are at most $M$, then $|\sum_{s \in S} p_i(s)| \leq N C M^l$ for all $p_i$. So one polynomial can have at most $(2 N C M^l +1 )$ different values. So the tuple of all $k$ polynomials can have at most $(2 N C M^l +1)^k$ different values.
But there are $\binom{M+1}{N}$ such sets. Choosing $N = kl+1$, this is a polynomial of $M$ with degree $kl+1$. So you can always pick a large enough $M$ to ensure this is more than $(2 (kl+1) C M^l)^k$.